1: 14 percent / p-TsOH / xylene / 20 h / Heating 2: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 3: TsOH / methanol / 0.33 h / Ambient temperature 4: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 5: diethyl ether; methanol View Scheme

2: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 3: TsOH / methanol / 0.33 h / Ambient temperature 4: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 5: diethyl ether; methanol View Scheme

1: 90 percent / (EtOPO2)4 / CHCl3 / 5 h / 80 °C 3: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 4: TsOH / methanol / 0.33 h / Ambient temperature 5: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 6: diethyl ether; methanol View Scheme

1: picric acid 2: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 3: TsOH / methanol / 0.33 h / Ambient temperature 4: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 5: diethyl ether; methanol View Scheme

1: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 2: TsOH / methanol / 0.33 h / Ambient temperature 3: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 4: diethyl ether; methanol View Scheme

1: 25percent aq. NH3 / acetone / 2 h 2: 90 percent / (EtOPO2)4 / CHCl3 / 5 h / 80 °C 4: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 5: TsOH / methanol / 0.33 h / Ambient temperature 6: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 7: diethyl ether; methanol View Scheme

1: 1) BuLi; 2) H2O / tetrahydrofuran; hexane; hexamethylphosphoric acid triamide / 1) r.t., 2 h 2: TsOH / methanol / 0.33 h / Ambient temperature 3: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 4: diethyl ether; methanol View Scheme

1: 96 percent / 1) 0.02N H2SO4; 2) 2N KOH / ethyl acetate; dioxane / 1) reflux, 30 min; 2) reflux, 30 min 2: diethyl ether; methanol View Scheme

in methanol; diethyl ether

1: 98 percent / quinoline, H2 / 5percent Pd/Lindlar / cyclohexane / 0.75 h 2: 95 percent / 2N KOH / methanol View Scheme