1-(2-氟-5-硝基苯基)乙-1-酮合成路线 （共 6 条）
反应条件
sulfuric acid; nitric acid T=-42°C; 0.5 h;
参考文献
SCHERING CORPORATION; STAMFORD, Andrew, W.; CUMMING, Jared, N.
Patent: WO2011/44184 A1, 2011 ;
Location in patent: Page/Page column 99-100 ;
WO 2011/044184 A1
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in toluene T=110°C; 48 h; 2: With hydrogenchloride in water; toluene T=20°C; 0.666667 h;
参考文献
WO2005/35520 A1, ;
Page/Page column 59-60 ;
反应条件
1: methylmagnesium bromide With zinc dibromide in tetrahydrofuran; diethyl ether T=-78 - 20°C; 2: 2-fluoro-5-nitro-benzoyl chloride With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; diethyl ether T=-78 - 20°C; Further stages.;
参考文献
Fang, Yuan-Qing; Lautens, Mark
Journal of Organic Chemistry, 2008 , vol. 73, # 2 p. 538 - 549
反应条件
hydrazine in ethylene glycol T=20 - 165°C; 26 h;
参考文献
Nagarathnam, Dhanapalan; Khire, Uday; Asgari, Davoud; Shao, Jianxing; Liu, Xiao-Gao; Wang, Chunguang; Hart, Barry; Weber, Olaf; Lynch, Mark; Zhang, Lei; Wang, Lei
Patent: US2004/14755 A1, 2004 ;
Location in patent: Page/Page column 21 ;
US 20040014755 A1
反应条件
hydrogenchloride; iron in ethanol; water 2 h; Heating;
参考文献
Zhang; Haemers; Vanden Berghe; Pattyn; Bollaert; Levshin
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 3 p. 673 - 683
反应条件
sodium hydroxide in ethyl acetate
参考文献
Synthelabo
Patent: US6214882 B1, 2001 ;
US 6214882 B1
