1,2,3,4-四氢-8-硝基异喹啉合成路线 （共 7 条）
反应条件
hydrogenchloride in methanol; water
10 h; Heating / reflux;
参考文献
BUOLAMWINI, John, K,
Patent: WO2004/60902 A2, 2004 ;
Location in patent: Page/Page column 18 ;
WO 2004/060902 A2
反应条件
hydrogenchloride in methanol
10 h; Heating;
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1.1: 50 percent / KNO3; H2SO4 / 5 - 20 °C
2.1: 94 percent / Et3N / CH2Cl2 / 1 h / Heating
3.1: FeCl3*6H2O; activated carbon / methanol / 0.33 h / Heating
3.2: 85 percent / NH2NH2*H2O / methanol / 4 h / Heating
4.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating
5.1: H2SO4; KNO3 / 0 °C
5.2: 0.5 g / aq. HCl / methanol / 0.83 h / Heating
6.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
6.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
7.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1.1: 94 percent / Et3N / CH2Cl2 / 1 h / Heating
2.1: FeCl3*6H2O; activated carbon / methanol / 0.33 h / Heating
2.2: 85 percent / NH2NH2*H2O / methanol / 4 h / Heating
3.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating
4.1: H2SO4; KNO3 / 0 °C
4.2: 0.5 g / aq. HCl / methanol / 0.83 h / Heating
5.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
5.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
6.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating
2.1: H2SO4; KNO3 / 0 °C
2.2: 0.5 g / aq. HCl / methanol / 0.83 h / Heating
3.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
3.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
4.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1.1: FeCl3*6H2O; activated carbon / methanol / 0.33 h / Heating
1.2: 85 percent / NH2NH2*H2O / methanol / 4 h / Heating
2.1: 94 percent / TFA / CH2Cl2 / 0.25 h / Heating
3.1: H2SO4; KNO3 / 0 °C
3.2: 0.5 g / aq. HCl / methanol / 0.83 h / Heating
4.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
4.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
5.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
反应条件
1.1: aq. NaNO2; aq. HCl / 2 h / 0 °C
1.2: 86 percent / aq. H3PO2 / 10 h / 40 °C
2.1: aq. HCl / methanol / 10 h / Heating
View Scheme
参考文献
Zhu, Zhengxiang; Furr, John; Buolamwini, John K.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 831 - 837
