N-乙酰基-2-溴-4-甲氧基苯胺合成路线 （共 8 条）
反应条件
1: 64 percent / tri-o-tolylphosphine, triethylamine / palladium(II) acetate / acetonitrile / 24 h / 120 °C / 22800 Torr 2: 54 percent / oxygen / palladium(II) chloride, copper(I) chloride / 1,2-dimethoxy-ethane / 760 Torr View Scheme
参考文献
Kasahara, Akira; Izumi, Taeko; Murakami, Satoshi; Miyamoto, Kazuhiro; Hino, Toshimi
Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 1405 - 1413
反应条件
sodium hydroxide; tributyl-amine; water; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride 1) 110-125 deg C, 2-3 atm, 7 h, 2) H2O, EtOH, 95 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Valentine, Donald; Tilley, Jefferson W.; LeMahieu, Ronald A.
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4614 - 4617
参考文献
Kajiyama, Daichi; Inoue, Keisuke; Ishikawa, Yuichi; Nishiyama, Shigeru
Tetrahedron, 2010 , vol. 66, # 52 p. 9779 - 9784
反应条件
boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene
T=20°C; 2 h; regioselective reaction;
参考文献
Liu, Huan; Wang, Xuemin; Gu, Yonghong
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 5 p. 1614 - 1620
反应条件
1: 79 percent / Fe, cc. HCl / ethanol / Heating
2: 87 percent
View Scheme
参考文献
Wright; Shulkind; Jones; Thompson
Tetrahedron Letters, 1987 , vol. 28, # 50 p. 6389-6390
反应条件
1: 47 percent / sodium nitrite, H2SO4
2: 95 percent / K2CO3 / acetone
3: 79 percent / Fe, cc. HCl / ethanol / Heating
4: 87 percent
View Scheme
参考文献
Wright; Shulkind; Jones; Thompson
Tetrahedron Letters, 1987 , vol. 28, # 50 p. 6389-6390
反应条件
1: 95 percent / K2CO3 / acetone
2: 79 percent / Fe, cc. HCl / ethanol / Heating
3: 87 percent
View Scheme
参考文献
Wright; Shulkind; Jones; Thompson
Tetrahedron Letters, 1987 , vol. 28, # 50 p. 6389-6390
反应条件
tributyl-amine; water; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride
T=110 - 125°C; P=1520 - 2280 Torr; 7 h;
参考文献
Valentine, Donald; Tilley, Jefferson W.; LeMahieu, Ronald A.
Journal of Organic Chemistry, 1981 , vol. 46, # 22 p. 4614 - 4617
