外消旋-5,6,7,8-四氢-6-(丙基氨基)-1-萘酚合成路线 （共 8 条）
反应条件
sodium sulfite in anhydrous xylene 60 h; Reflux;
参考文献
SHAN DONG LUYE PHARMACEUTICAL CO., LTD.; Meng, Qingguo; Yang, Mina; Wang, Tao; Wang, Qilin; Li, Jun; Ruan, Zheng
Patent: US2014/121380 A1, 2014 ;
Location in patent: Paragraph 0059 ;
反应条件
1.1: acetonitrile; water / 2 h / 0 - 5 °C 2.1: potassium carbonate / toluene / 60 °C 3.1: sodium hydrogencarbonate / acetonitrile / 9 h / Reflux 3.2: pH 1 - 2 3.3: pH 7 - 7.5 View Scheme
反应条件
boron tribromide in dichloromethane
T=-40 - 20°C;
参考文献
Biswas, Swati; Zhang, Suhong; Fernandez, Fernando; Ghosh, Balaram; Zhen, Juan; Kuzhikandathil, Eldo; Reith, Maarten E. A.; Dutta, Aloke K.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 1 p. 101 - 117
反应条件
1: NaBH3CN, AcOH / methanol
2: 48percent aq. HBr
View Scheme
参考文献
van Vliet; Tepper; Dijkstra; Damsma; Wikstroem; Pugsley; Akunne; Heffner; Glase; Wise
Journal of medicinal chemistry, 1996 , vol. 39, # 21 p. 4233 - 4237
反应条件
1: acetonitrile; water / 2 h / 0 - 5 °C
2: potassium carbonate / toluene / 60 °C
View Scheme
参考文献
Marquillas Olondriz, Francisco; Pomares Marco, Marta
Patent: US2011/152543 A1, 2011 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=50°C; 60 h;
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=50°C; 60 h;
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
T=50°C; 60 h;
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
