5-羟基-4-丙基-2(5H)-呋喃酮合成路线 （共 6 条）
反应条件
1: formyl formic acid With morpholine in n-heptane; water T=20°C; 1 h; 2: pentanal in n-heptane; water T=43°C; 20 h; 3: With hydrogenchloride in n-heptane; water T=20°C; 2 h;
参考文献
UCB, S.A.
Patent: WO2005/28435 A1, 2005 ;
Location in patent: Page/Page column 8 ;
反应条件
1: formyl formic acid With morpholine in n-heptane; water T=0 - 20°C; 1 h; 2: pentanal in n-heptane; water T=45°C; 20 h; 3: With hydrogenchloride in n-heptane; water T=20°C; 2 h;
参考文献
WO2011/86565 A1, ;
Page/Page column 23-24 ;
反应条件
morpholine hydrochloride in 1,4-dioxane; water 1) RT, 1 h, 2) 24 h, reflux;
参考文献
Bourguignon, J. J.; Wermuth, C. G.
Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894
反应条件
hydrogenchloride 0.25 h; Heating; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 46, # 24 p. 4889 - 4894
反应条件
1: in isopropyl alcohol T=15 - 30°C; 2 h; 2: With hydrogen; acetic acid; palladium on activated carbon in isopropyl alcohol T=40°C; P=150.015 - 375.038 Torr; 20 h; Product distribution / selectivity;
参考文献
UCB, S.A.
Patent: WO2005/28435 A1, 2005 ;
Location in patent: Page/Page column 8-1- ;
参考文献
Kenda, Benoit M.; Matagne, Alain C.; Talaga, Patrice E.; Pasau, Patrick M.; Differding, Edmond; Lallemand, Benedicte I.; Frycia, Anne M.; Moureau, Florence G.; Klitgaard, Henrik V.; Gillard, Michel R.; Fuks, Bruno; Michel, Philippe
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 530 - 549
