2-氯-5-(三氟甲基)苯甲酮合成路线 （共 4 条）
反应条件
1: (i) NaNO2, H2SO4, (ii) aq. ZnCl2, (iii) /BRN= 3587243/, CuCN, aq. NaHCO3, PE
2: (i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene
View Scheme
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
(i) Et2O, benzene, (ii) HCl, (iii) aq. H2SO4, toluene; Multistep reaction;
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
ammonium hydroxide; copper(l) chloride in 1,4-dioxane
T=140°C;
参考文献
Saucy,G.; Sternbach,L.H.
Helvetica Chimica Acta, 1962 , vol. 45, p. 2226 - 2241
反应条件
1: dimethylformamide / Heating
2: aq. NaOH
View Scheme
参考文献
Bigler,A.J. et al.
European Journal of Medicinal Chemistry, 1977 , vol. 12, p. 289 - 295
