1-碘-3-[(叔-丁基二甲基硅烷基)氧基]丙烷合成路线 （共 9 条）
反应条件
Product distribution;
参考文献
Ochiai, Masahito; Iwaki, Shigeru; Ukita, Tatsuzo; Nagao, Yoshimitsu
Chemistry Letters, 1987 , p. 133 - 136
反应条件
1: tert-Butyl-(3-iodo-propoxy)-dimethyl-silane With tert.-butyl lithium; oxygen in diethyl ether; pentane T=-78 - 23°C; Inert atmosphere; 2: C12H22FNO4 in diethyl ether; pentane T=-78°C; 1 h; Inert atmosphere;
参考文献
Jakobsche, Charles E.; Peris, Gorka; Miller, Scott J.
Angewandte Chemie - International Edition, 2008 , vol. 47, # 35 p. 6707 - 6711
反应条件
triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=20°C; 16 h;
参考文献
Schreiber, Stuart L.; Stavenger, Robert A.; Mitchison, Timothy J.; Maliga, Zoltan
Patent: US2004/59138 A1, 2004 ;
Location in patent: Page 38 ;
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
15 h; Ambient temperature;
参考文献
Fuerstner, Alois; Bonnekessel, Melanie; Blank, Jarred T.; Radkowski, Karin; Seidel, Guenter; Lacombe, Fabrice; Gabor, Barbara; Mynott, Richard
Chemistry - A European Journal, 2007 , vol. 13, # 31 p. 8762 - 8783
反应条件
sodium iodide in acetone
T=60°C; Finkelstein reaction; 0.333333 h; Inert atmosphere;
参考文献
Thompson, Christina M.; Quinn, Catherine A.; Hergenrother, Paul J.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 1 p. 117 - 125
反应条件
sodium iodide in acetone
12 h; Reflux;
参考文献
Zhou, Shiqiang; Jia, Yanxing
Organic Letters, 2014 , vol. 16, # 12 p. 3416 - 3418
反应条件
calcium carbonate; sodium iodide in dichloromethane
48 h; Heating;
参考文献
Gu, Xiaorong; Sun, Mingjiang; Gugiu, Bogdan; Hazen, Stanley; Crabb, John W.; Salomon, Robert G.
Journal of Organic Chemistry, 2003 , vol. 68, # 10 p. 3749 - 3761
反应条件
1: 41.4 g / imidazole / dimethylformamide / Ambient temperature
2: NaI / acetone / 72 h / Ambient temperature
View Scheme
参考文献
Tanner, David; Hagberg, Lars
Tetrahedron, 1998 , vol. 54, # 27 p. 7907 - 7918
反应条件
1.1: LDA / tetrahydrofuran / -78 °C
1.2: LDA / tetrahydrofuran / -78 - 0 °C
2.1: LDA / tetrahydrofuran / 1 h / -78 °C
3.1: LiAlH4 / diethyl ether / 0.5 h / 20 °C
4.1: Dess-Martin periodinane / 18 h / 20 °C
View Scheme
参考文献
Azzi, Nadia; Griffen, Ed; Light, Mark; Linclau, Bruno
Chemical Communications, 2006 , # 47 p. 4909 - 4911
