3-(4-联苯基)-1-丙醇合成路线 （共 20 条）
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene
1 h; Heating;
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
lithium aluminium tetrahydride
参考文献
Kigawa, Hitoshi; Takamuku, Setsuo; Toki, Susumu; Kimura, Norio; Takeda, Seishi; et al.
Journal of the American Chemical Society, 1981 , vol. 103, # 17 p. 5176 - 5179
反应条件
1: K2CO3, 18-crown-6 / acetone / Heating
2: 25 percent / Bu3SnH, AIBN / benzene / 1 h / Heating
View Scheme
参考文献
Lee, Eun; Lee, Chulbom; Tae, Jin Sung; Whang, Ho Sung; Li, Kap Sok
Tetrahedron Letters, 1993 , vol. 34, # 14 p. 2343 - 2346
反应条件
1: 20 palladium(II) hydroxide on carbon; hydrogen / methanol / 3 h
2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C / |Inert atmosphere
View Scheme
参考文献
ALECTOS THERAPEUTICS INC.; MERCK SHARP and DOHME CORP.; MCEACHERN, Ernest J.; SUN, Jianyu; VOCADLO, David J.; ZHOU, Yuanxi; ZHU, Yongbao; SELNICK, Harold G.
Patent: WO2014/32188 A1, 2014 ;
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating
2: 1.) Li, MeI / 1.) THF, -15 deg C, 45 min, 2.) -75 deg C, 24 min
View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
Dess-Martin periodane in dichloromethane
T=20°C; 1 h;
参考文献
ALECTOS THERAPEUTICS INC.; MERCK SHARP and DOHME CORP.; MCEACHERN, Ernest J.; SUN, Jianyu; VOCADLO, David J.; ZHOU, Yuanxi; ZHU, Yongbao; SELNICK, Harold G.
Patent: WO2014/32188 A1, 2014 ;
Location in patent: Paragraph 00165 ;
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating
2: Cs-K-Na alloy / tetrahydrofuran / -75 °C
View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating
2: Cs-K-Na alloy / tetrahydrofuran / 0.01 h / -75 °C
View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
pyridine; thionyl chloride
0.333333 h; Heating;
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
反应条件
1: 90 percent / thionyl chloride, pyridine / 0.33 h / Heating
2: Cs-K-Na alloy / tetrahydrofuran / 0.01 h / -75 °C
View Scheme
参考文献
Grovenstein, Erling; Lu, Pang-Chia
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2928 - 2939
