(S)-(-)-2-氨基-4-甲基-1,1-二苯基-1-戊醇合成路线 （共 12 条）
反应条件
sodium borohydride; acetic acid in N-methyl-acetamide; dichloromethane; chloroform
参考文献
Sumitomo Chemical Company, Limited
Patent: US4908455 A1, 1990 ;
反应条件
in tetrahydrofuran
T=0 - 20°C; Grignard reaction; Inert atmosphere;
参考文献
Belanger, Etienne; Pouliot, Marie-France; Courtemanche, Marc-Andre; Paquin, Jean-Francois
Journal of Organic Chemistry, 2012 , vol. 77, # 1 p. 317 - 331
反应条件
1: bromobenzene With magnesium in diethyl ether
T=40°C; Inert atmosphere;
2: (L)-leucine methyl ester hydrochloride in diethyl ether
T=0 - 20°C; 15.5 h;
参考文献
Berkessel, Albrecht; Harnying, Wacharee; Duangdee, Nongnaphat; Neudoerfl, Joerg-M.; Groeger, Harald
Organic Process Research and Development, 2012 , vol. 16, # 1 p. 123 - 128
反应条件
in tetrahydrofuran
T=0 - 10°C; Addition;
参考文献
Wu, Yangjie; Yun, Hongying; Wu, Yusheng; Ding, Kuiling; Zhou, Ying
Tetrahedron Asymmetry, 2000 , vol. 11, # 17 p. 3543 - 3552
反应条件
1: [14C]-L-(+)-Leucine With thionyl chloride in methanol
T=-30 - 20°C;
2: 2 h; Heating;
3: Bromure de phenyl magnesium in tetrahydrofuran
T=20°C; 24 h;
参考文献
Kang, Yong-Feng; Wang, Rui; Liu, Lei; Da, Chao-Shan; Yan, Wen-Jin; Xu, Zhao-Qing
Tetrahedron Letters, 2005 , vol. 46, # 5 p. 863 - 865
反应条件
1: SOCl2 / methanol / 2 h / Heating
2: tetrahydrofuran
View Scheme
参考文献
Kang, Yong-Feng; Liu, Lei; Wang, Rui; Yan, Wen-Jin; Zhou, Yi-Feng
Tetrahedron Asymmetry, 2004 , vol. 15, # 19 p. 3155 - 3159
反应条件
in tetrahydrofuran
T=20°C; Addition; 12 h;
参考文献
Kawanami, Yasuhiro; Mitsuie, Tomoko; Miki, Misuzu; Sakamoto, Takanobu; Nishitani, Kazumi
Tetrahedron, 2000 , vol. 56, # 2 p. 175 - 178
反应条件
1: H2O
2: diethyl ether
3: aq. HCl
View Scheme
参考文献
Lamant,M.; Guignard,A.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1975 , vol. 281, p. 123 - 126
反应条件
1: diethyl ether
2: aq. HCl
View Scheme
参考文献
Lamant,M.; Guignard,A.
Comptes Rendus des Seances de l'Academie des Sciences, Serie C: Sciences Chimiques, 1975 , vol. 281, p. 123 - 126
参考文献
Kang, Yong-Feng; Liu, Lei; Wang, Rui; Yan, Wen-Jin; Zhou, Yi-Feng
Tetrahedron Asymmetry, 2004 , vol. 15, # 19 p. 3155 - 3159
