(R)-(+)-2-氨基-1,1-二苯基-1-丙醇合成路线 （共 4 条）
反应条件
1: in tetrahydrofuran T=0 - 20°C; 6 h; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=0 - 5°C; 1 h;
参考文献
LONZA LTD; LONZA GUANGZHOU RESEARCH AND DEVELOPMENT CENTER LTD; DAI, Danmei; LONG, Xiangtian; LUO, Bing; KULESZA, Anna; REICHWAGEN, Jens; GUO, Yanming
Patent: WO2012/97510 A1, 2012 ;
Location in patent: Page/Page column 61 ;
反应条件
in tetrahydrofuran T=20°C; 3 h;
参考文献
Itagaki, Makoto; Hagiya, Koji; Kamitamari, Masashi; Masumoto, Katsuhisa; Suenobu, Katsuhiro; Yamamoto, Yohsuke
Tetrahedron, 2004 , vol. 60, # 36 p. 7835 - 7843
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 64 ;
反应条件
magnesium in tetrahydrofuran T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Organic Process Research and Development, , vol. 11, # 3 p. 509 - 518
