(S)-2-氨基-1,1-二苯基-1-丙醇合成路线 （共 15 条）
反应条件
1: bromobenzene With iodine; magnesium in diethyl ether Heating; 2: (L)-alanine methyl ester in diethyl ether Grignard reaction; Heating;
参考文献
Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle
European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096
反应条件
chiral stationary phase including (R)-naphthylethyl-carbamate-functionalized CF6 in ethanol; n-heptane; trifluoroacetic acid T=20°C; Purification / work up;
参考文献
WO2010/148191 A2, ;
Page/Page column 45-49; 64 ;
反应条件
in tetrahydrofuran T=0 - 10°C;
参考文献
Cai, Lisheng; Mahmoud, Hussein; Han, Ying
Tetrahedron Asymmetry, 1999 , vol. 10, # 3 p. 411 - 427
反应条件
in tetrahydrofuran T=0 - 90°C; Grignard reaction;
参考文献
Jockel, Holger; Schmidt, Reinhard; Jope, Helge; Schmalz, Hans-Guenther
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 1 p. 69 - 76
参考文献
Weber, Edwin; Reutel, Christiane; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.
Journal of Physical Organic Chemistry, 1995 , vol. 8, p. 159 - 170
反应条件
1: 6M H2SO4 / methanol; tetrahydrofuran 2: 1.) BH3*Me2S, (2S)-α,α-diphenyl-2-aziridinemethanol, 2.) water / 1.) THF, reflux, 15 h View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 4 p. 603 - 606
反应条件
in tetrahydrofuran T=0 - 10°C; 8 h; Yield given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2039 - 2044
参考文献
Weber, Edwin; Reutel, Christiane; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 7 p. 1455 - 1462
反应条件
dimethylsulfide borane complex; water; [(S)-aziridin-2-yl](diphenyl)methanol 1.) THF, reflux, 15 h; Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 36, # 4 p. 603 - 606
反应条件
iodine; magnesium 1.) Et2O, reflux, 2.) 50 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Chemische Berichte, , vol. 126, # 11 p. 2449 - 2456
