3-氨基-4-羟基-苯乙酸甲酯合成路线 （共 8 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; ethyl acetate 72 h;
参考文献
OXFORD GLYCOSCIENCES (UK) LTD
Patent: WO2004/46122 A2, 2004 ;
Location in patent: Page 15-16 ;
反应条件
1: 90 percent / HCl / Heating 2: 92 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 9 p. 2295 - 2299
反应条件
1: acetic acid; nitric acid / 1 h / 0 °C 2: sulfuric acid / 70 °C / |Reflux 3: palladium 10 on activated carbon; hydrogen / tetrahydrofuran; methanol / 2 h / 20 °C View Scheme
参考文献
WO2013/19682 A1, ;
WO 2013/019682 A1
反应条件
1: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C 2: boron tribromide / dichloromethane / 4 h / -70 - 20 °C 3: hydrogen / methanol / 12 h / 20 °C View Scheme
反应条件
1: boron tribromide / dichloromethane / 4 h / -70 - 20 °C 2: hydrogen / methanol / 12 h / 20 °C View Scheme
反应条件
1: thionyl chloride / 1.5 h / 0 °C / |Reflux 2: acetic acid; nitric acid; acetic anhydride / 2 h / -30 - 20 °C 3: boron tribromide / dichloromethane / 4 h / -70 - 20 °C 4: hydrogen / methanol / 12 h / 20 °C View Scheme
反应条件
T=20°C; 12 h; Heating / reflux;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 102 ;
反应条件
sodium hydrogencarbonate in water; ethyl acetate
T=25°C; 1 h;
参考文献
Gruenenthal GmbH
Patent: US2010/234340 A1, 2010 ;
Location in patent: Page/Page column 23 ;
US 20100234340 A1
