1-(2-脱氧-beta-D-赤式-呋喃戊糖基)-1H-咪唑并[4,5-c]吡啶-4-胺合成路线 （共 27 条）
反应条件
hydrogenchloride T=25°C; τ/2 (N-glycosyl bond hydrolyses);
参考文献
Seela; Rosemeyer; Fischer
Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1602 - 1611
反应条件
hydrogenchloride T=25°C; τ/2 (N-glycosyl bond hydrolyses);
参考文献
Seela; Rosemeyer; Fischer
Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1602 - 1611
反应条件
hydrogenchloride T=25°C; τ/2 (N-glycosyl bond hydrolyses);
参考文献
Seela; Rosemeyer; Fischer
Helvetica Chimica Acta, 1990 , vol. 73, # 6 p. 1602 - 1611
反应条件
1: With hydrazine hydrate in water
T=95°C;
2: in ethanol; water
0.5 h; Reflux;
参考文献
Maiti, Munmun; Persoons, Leentje; Andrei, Graciela; Snoeck, Robert; Balzarini, Jan; Herdewijn, Piet
ChemMedChem, 2013 , vol. 8, # 6 p. 985 - 993
反应条件
potassium hydroxide; dipotassium hydrogenphosphate in water
T=37°C; 144 h; thymidine phosphorylase, purine nucleoside phosphorylase;
参考文献
Krenitsky; Rideout; Chao; Koszalka; Gurney; Crouch; Cohn; Wolberg; Vinegar
Journal of Medicinal Chemistry, 1986 , vol. 29, # 1 p. 138 - 143
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
2 h; Ambient temperature;
参考文献
Minakawa; Sasabuchi; Kiyosue; Kojima; Matsuda
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 2 p. 288 - 295
反应条件
1: 68 percent / KOH / tris<2-(2-methoxyethoxy)ethyl>amin (TDA-1) / acetonitrile / 0.25 h / Ambient temperature
2: 83 percent / 3-chloroperbenzoic acid (70percent) / methanol / 0.5 h / Ambient temperature
3: 85 percent / NH3, MeOH / 20 h / Ambient temperature
4: 47 percent / 25percent aq. NH3, 30percent H2O2 / 24 h / 60 °C
View Scheme
参考文献
Seela, Frank; Grein, Thomas; Samnick, Samuel
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1639 - 1650
反应条件
in aqueous hydrazine hydrate; water
参考文献
Burroughs Wellcome Co.
Patent: US4481197 A1, 1984 ;
参考文献
Burroughs Wellcome Co.
Patent: US4481197 A1, 1984 ;
反应条件
ammonium hydroxide; dihydrogen peroxide
T=60°C; 24 h;
参考文献
Seela, Frank; Grein, Thomas; Samnick, Samuel
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1639 - 1650
