3-(3-三氟甲基苯基)丙醇合成路线 （共 27 条）
反应条件
hydrogen; palladium 10 on activated carbon in isopropyl alcohol T=42 - 45°C; P=3750.38 Torr; 5 h;
参考文献
Medichem, S.A.
Patent: US2010/267988 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogen in methanol T=160°C; P=150015 Torr; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2011/118510 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; 25 h; 2: With water in tetrahydrofuran; methanol
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP2013209 B1, 2011 ;
Location in patent: Page/Page column 23 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; P=750.06 Torr; 26 h;
参考文献
Goument, B.; Duhamel, L.; Mauge, R.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 459 - 466
反应条件
1: 82 percent / (R,R)-diethyl tartrate, titanium tetra iso-propoxide, tert-butyl hydroperoxide / CH2Cl2 / 24 h / -23 °C 2: 100 percent / hydrogen / 5 percent Pd/C / ethanol / 19 h / 20 °C 3: 87 percent / pyridine / 14.5 h / 0 °C 4: 8 percent / lithium aluminum hydride / diethyl ether / 3 h / 21 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
hydrogen; Lindlar's catalyst in ethanol T=20°C; P=750.06 Torr; 25 h; Yield given. Yields of byproduct given;
参考文献
Bulletin de la Societe Chimique de France, , vol. 130, p. 459 - 466
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 24 h; 2: With ethanol; water in ethyl acetate Product distribution / selectivity;
参考文献
WO2006/125026 A2, ;
Page/Page column 25 ;
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 24 h; 2: With ethanol; water in ethyl acetate Product distribution / selectivity;
参考文献
WO2006/125026 A2, ;
Page/Page column 24-25 ;
反应条件
1: With sodium tetrahydroborate in ethanol T=20°C; 24 h; 2: With ethanol; water in ethyl acetate Product distribution / selectivity;
参考文献
WO2006/125026 A2, ;
Page/Page column 25 ;
反应条件
1: hydrogen / palladium 10 on activated carbon / methanol / 2.5 h / 750.08 Torr 2: borane / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere View Scheme
