4-溴-2-[(5-溴-2-羟基苯基)甲基]苯酚合成路线 （共 10 条）
反应条件
1: sodium 2: 150 - 160 °C View Scheme
参考文献
Buehler; Cooper; Scrudder
Journal of Organic Chemistry, 1943 , vol. 8, p. 316,318
反应条件
potassium hydroxide; zinc
参考文献
Moshfegh, Ali A.; Badri, Rashid; Hojjatie, Massoud; Kaviani, Mehrangiz; Naderi, Basirat; et al.
Helvetica Chimica Acta, 1982 , vol. 65, # 4 p. 1221 - 1228
参考文献
Buehler; Cooper; Scrudder
Journal of Organic Chemistry, 1943 , vol. 8, p. 316,318
反应条件
1: 77 percent / acetylation 2: 60 percent / AlCl3 3: 51 percent / sodium hypoiodide View Scheme
参考文献
Moshfegh, Ali A.; Badri, Rashid; Hojjatie, Massoud; Kaviani, Mehrangiz; Naderi, Basirat; et al.
Helvetica Chimica Acta, 1982 , vol. 65, # 4 p. 1221 - 1228
反应条件
sulfuric acid
T=-10 - 0°C; 18 h;
参考文献
Haddad, Nizar; Xu, Yibo; Baron, James A.; Yee, Nathan K.
Tetrahedron Letters, 2002 , vol. 43, # 7 p. 1135 - 1137
反应条件
sulfuric acid in methanol
T=-10 - 5°C; 6 h;
参考文献
Hakimelahi, Gholam Hosein; Moshfegh, Ali Akbar
Helvetica Chimica Acta, 1981 , vol. 64, # 2 p. 599 - 609
反应条件
bromine; acetic acid in dichloromethane
T=20°C; 2 h;
参考文献
Oh, Ki-Bong; Lee, Ji Hye; Chung, Soon-Chun; Shin, Jongheon; Shin, Hee Jae; Kim, Hye-Kyeong; Lee, Hyi-Seung
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 1 p. 104 - 108
反应条件
toluene-4-sulfonic acid
1.) benzene, reflux, 2.) benzene, reflux, 15 h; Yield given. Multistep reaction;
参考文献
Shiomi, Yutaka; Saisho, Miwako; Tsukagoshi, Kazuhiko; Shinkai, Seiji
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 17 p. 2111 - 2118
参考文献
Buehler; Cooper; Scrudder
Journal of Organic Chemistry, 1943 , vol. 8, p. 316,318
反应条件
1: 77 percent / acetylation
2: 60 percent / AlCl3
3: 51 percent / sodium hypoiodide
4: Zn/KOH
View Scheme
参考文献
Moshfegh, Ali A.; Badri, Rashid; Hojjatie, Massoud; Kaviani, Mehrangiz; Naderi, Basirat; et al.
Helvetica Chimica Acta, 1982 , vol. 65, # 4 p. 1221 - 1228
