4-苄基-3-氧代哌嗪-1-羧酸叔丁酯合成路线 （共 8 条）
反应条件
1: 85 percent / TFA / 0.33 h / 0 °C 2: 70 percent / aq. H2O2 / Na2WO4*2H2O / ethanol / 6 h View Scheme
参考文献
Bernotas, Ronald C.; Adams, Ginette
Tetrahedron Letters, 1996 , vol. 37, # 41 p. 7339 - 7342
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Haley, Gregory Jay; Kong, Norman; Liu, Emily Aijun; Simonsen, Klaus B.; Vu, Binh Thanh; Webber, Stephen Evan
Patent: US2004/259884 A1, 2004 ;
Location in patent: Page 13 ;
反应条件
1: With trifluoroacetic acid in dichloromethane 18 h; 2: With sodium hydroxide in dichloromethane; water pH=12;
参考文献
Roche Palo Alto LLC
Patent: US2009/209553 A1, 2009 ;
Location in patent: Page/Page column 15 ;
反应条件
1: 1-tert-Butoxycarbonyl-3-oxopiperazine With sodium hydride in tetrahydrofuran
T=0°C; 1.75 h; Inert atmosphere;
2: benzyl bromide in tetrahydrofuran
T=20°C; 18 h; Inert atmosphere;
参考文献
Roche Palo Alto LLC
Patent: US2009/209553 A1, 2009 ;
Location in patent: Page/Page column 14-15 ;
反应条件
1: 1-tert-Butoxycarbonyl-3-oxopiperazine With sodium hydride in DMF (N,N-dimethyl-formamide)
T=20°C; 2 h;
2: benzyl bromide in DMF (N,N-dimethyl-formamide)
T=70°C; 16 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC
Patent: WO2005/16876 A2, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/016876 A2
反应条件
sodium hydride in N,N-dimethyl-formamide
T=0 - 20°C; 4.5 h;
参考文献
SCHERING CORPORATION
Patent: WO2006/14944 A1, 2006 ;
Location in patent: Page/Page column 29-30 ;
WO 2006/014944 A1
反应条件
in ethyl acetate; benzene
参考文献
The Upjohn Company
Patent: US4251438 A1, 1981 ;
参考文献
Cumming; Le; Babu; Carroll; Chen; Favreau; Gaspari; Guo; Hobbs; Huang; Iserloh; Kennedy; Kuvelkar; Li; Lowrie; McHugh; Ozgur; Pan; Parker; Saionz; Stamford; Strickland; Tadesse; Voigt; Wang; Wu; Zhang
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 11 p. 3236 - 3241
