2-氨基-5-氯-2'-氟二苯甲酮合成路线 （共 17 条）
反应条件
2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; oxygen; copper(II) bis(trifluoromethanesulfonate); (R)-(+)-1,1'-binaphthyl-2,2'-diamine in toluene T=80°C; 18 h; optical yield given as percent ee;
参考文献
Mannam, Sreedevi; Sekar, Govindasamy
Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 497 - 502
反应条件
zinc(II) chloride T=200 - 230°C; 3 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 38, # 3 p. 663 - 669
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 1.2: 1.25 h / -40 °C / Inert atmosphere 2.1: hydrogenchloride; water / ethanol / Reflux 2.2: pH 8 View Scheme
参考文献
Molecules, , vol. 16, # 9 p. 7649 - 7661
反应条件
1.1: N-ethyl-N,N-diisopropylamine / toluene / 20 °C 2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere 2.2: 1.25 h / -40 °C / Inert atmosphere 3.1: hydrogenchloride; water / ethanol / Reflux 3.2: pH 8 View Scheme
参考文献
Molecules, , vol. 16, # 9 p. 7649 - 7661
反应条件
hydrogenchloride multistep reaction: biotransformation, acid hydrolysis;
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 32, # 3 p. 177 - 183
反应条件
N-ethyl-N,N-diisopropylamine in toluene T=10 - 20°C; 3.5 h;
参考文献
Cheng, Pi; Zhang, Quan; Ma, Yun-Bao; Jiang, Zhi-Yong; Zhang, Xue-Mei; Zhang, Feng-Xue; Chen, Ji-Jun
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 13 p. 3787 - 3789
反应条件
Raney aluminium-nickel alloy; water; sodium hydroxide in dimethoxymethane T=25°C; 17 h;
参考文献
Weidlich, Tomas; Prokes, Lubomir
Central European Journal of Chemistry, 2011 , vol. 9, # 4 p. 590 - 597
反应条件
1: With dicyclohexyl-carbodiimide in toluene T=150°C; 0.5 h; Microwave irradiation; 2: With trifluoroacetic acid in toluene T=150°C; 0.333333 h; Microwave irradiation;
参考文献
Mwande-Maguene, Gabin; Jakhlal, Jouda; Lekana-Douki, Jean-Bernard; Mouray, Elisabeth; Bousquet, Till; Pellegrini, Sylvain; Grellier, Philippe; Ndouo, Fousseyni Samba Toure; Lebibi, Jacques; Pelinski, Lydie
New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2412 - 2415
反应条件
1: H2O / CH2Cl2 / 20 °C 2: 18.65 g / NH3 / methanol / 45 °C View Scheme
参考文献
Mwande-Maguene, Gabin; Jakhlal, Jouda; Lekana-Douki, Jean-Bernard; Mouray, Elisabeth; Bousquet, Till; Pellegrini, Sylvain; Grellier, Philippe; Ndouo, Fousseyni Samba Toure; Lebibi, Jacques; Pelinski, Lydie
New Journal of Chemistry, 2011 , vol. 35, # 11 p. 2412 - 2415
反应条件
sodium hydroxide; tetrabutylammomium bromide in tetrahydrofuran T=60°C; 2 h;
参考文献
Synthesis, , # 6 p. 448 - 449
