3-溴甲基-3-甲基-1-氧杂环丁烷合成路线 （共 10 条）
反应条件
sodium bromide in acetone 30 h; Heating;
参考文献
Samsung Electronics Co., Ltd.; Korea Advanced Institute of Science and Technology
Patent: EP1927592 A1, 2008 ;
Location in patent: Page/Page column 11 ;
参考文献
EP1081137 A1, ;
EP 1081137 A1
反应条件
1: 81 percent / diethyl carbonate, KOH / ethanol / 2 h / Heating 2: 47 percent / triphenylphosphine, pyridine, Br2 / CHCl3 / 2 h / Ambient temperature View Scheme
参考文献
Acta Chemica Scandinavica, , vol. 45, # 1 p. 82 - 91
反应条件
1: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 2: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
反应条件
potassium hydroxide; tetrabutylammomium bromide in water T=80 - 85°C; 7 h;
参考文献
Fujiwara, Tomoko; Makal, Umit; Wynne, Kenneth J.
Macromolecules, 2003 , vol. 36, # 25 p. 9383 - 9389
反应条件
1: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h 2: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
反应条件
1: 1.) Cs2CO3 / 1.) H2O, 20 min, 2.) DMF, room temperature, 24 h
2: 1.) BF3*Et2O, 2.) TEA / 1.) CH2Cl2, 0 deg C to room temperature, 6 h, 2.) 30 min
View Scheme
参考文献
Blaskovich, Mark A.; Evindar, Ghotas; Rose, Nicholas G. W.; Wilkinson, Scott; Luo, Yue; Lajoie, Gilles A.
Journal of Organic Chemistry, 1998 , vol. 63, # 11 p. 3631 - 3646
参考文献
Fujiwara, Tomoko; Wynne, Kenneth J.
Macromolecules, 2004 , vol. 37, # 23 p. 8491 - 8494
反应条件
1: ethanol / 80 °C
2: hydrogen; ammonia / palladium 10 on activated carbon; platinum(IV) oxide / methanol / 2585.81 Torr
View Scheme
参考文献
AMBIT BIOSCIENCES CORPORATION; ABRAHAM, Sunny; HOLLADAY, Mark, W.; LIU, Gang; XU, Shimin
Patent: WO2011/22473 A1, 2011 ;
WO 2011/022473 A1
反应条件
sodium hydride in tetrahydrofuran; mineral oil
T=65°C; 4 h; Inert atmosphere;
参考文献
Harada, Nari-Aki; Yasuhara, Jushiro; Motoyama, Yukihiro; Fujimura, Osamu; Tsuji, Tetsuro; Takahashi, Takeshi; Takahashi, Yoshiaki; Nagashima, Hideo
Bulletin of the Chemical Society of Japan, 2011 , vol. 84, # 1 p. 26 - 39
