1: methyl malonic acid diethylester With sodium hydride in tetrahydrofuran
T=0°C;
2: (E)-2-butenyl triflate With substituted-biphenyl-phosphoramideite; [(η3-allyl)Pd(OAc)]2 in tetrahydrofuran
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Boele, Maarten D. K.; Kamer, Paul C. J.; Lutz, Martin; Spek, Anthony L.; De Vries, Johannes G.; Van Leeuwen, Piet W. N. M.; Van Strijdonck, Gino P. F.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6232 - 6246
1: methyl malonic acid diethylester With sodium hydride in tetrahydrofuran
T=0°C;
2: trans-crotonyl chloride With substituted-biphenyl-phosphoramideite; [(η3-allyl)Pd(OAc)]2 in tetrahydrofuran
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Boele, Maarten D. K.; Kamer, Paul C. J.; Lutz, Martin; Spek, Anthony L.; De Vries, Johannes G.; Van Leeuwen, Piet W. N. M.; Van Strijdonck, Gino P. F.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6232 - 6246
1: methyl malonic acid diethylester With sodium hydride in tetrahydrofuran
T=0°C;
2: (E)-crotyl acetate With substituted-biphenyl-phosphoramideite; [(η3-allyl)Pd(OAc)]2 in tetrahydrofuran
T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Boele, Maarten D. K.; Kamer, Paul C. J.; Lutz, Martin; Spek, Anthony L.; De Vries, Johannes G.; Van Leeuwen, Piet W. N. M.; Van Strijdonck, Gino P. F.
Chemistry - A European Journal, 2004 , vol. 10, # 24 p. 6232 - 6246
1: methyl malonic acid diethylester With sodium hydride in tetrahydrofuran
T=-0.16°C; deprotonation;
2: (E)-crotyl acetate With [Pd(C4H7){o-C5H4N(CH2)2OPPh2}][O3SCF3] in tetrahydrofuran
T=18.84°C; Alkylation; 24 h; Further stages. Title compound not separated from byproducts.;
参考文献
Van Haaren, Richard J.; Druijven, Cees J. M.; Van Strijdonck, Gino P. F.; Oevering, Henk; Reek, Joost N. H.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
Journal of the Chemical Society, Dalton Transactions, 2000 , # 10 p. 1549 - 1554
1: methyl malonic acid diethylester With sodium hydride in tetrahydrofuran
T=-0.16°C; deprotonation;
2: trans-crotonyl chloride With ((C4H7)PdNC5H4(CH2)OP(C6H5)2)(1+)*CF3SO3(1-)=((C4H7)PdNC5H4(CH2)OP(C6H5)2)(CF3SO3) in tetrahydrofuran
T=18.84°C; Alkylation; Further stages. Title compound not separated from byproducts.;
参考文献
Van Haaren, Richard J.; Druijven, Cees J. M.; Van Strijdonck, Gino P. F.; Oevering, Henk; Reek, Joost N. H.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
Journal of the Chemical Society, Dalton Transactions, 2000 , # 10 p. 1549 - 1554
