5-羟基苯并[c]芴-7-酮合成路线 （共 17 条）
反应条件
sulfuric acid in water; acetic acid
6 h; Heating;
参考文献
Krepelka, Jiri; Vancurova, Iva; Holubek, Jiri; Roubik, Jiri
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 9 p. 2207 - 2216
反应条件
hydrogen bromide; acetic acid
5 h; Heating;
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
sulfuric acid in water; acetic acid
10 h; Heating;
参考文献
Krepelka, Jiri; Vancurova, Iva; Holubek, Jiri; Roubik, Jiri
Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 9 p. 2207 - 2216
反应条件
1: 10.80 g / NaOH / H2O / 3 h / Heating
2: oxalyl chloride / CH2Cl2 / 24 h / 20 °C
3: Et3N / 1,2-dichloro-ethane / 20 °C
4: 1.027 g / SOCl2 / CH2Cl2; benzene / 4 h / 20 °C
5: 75 percent / diethyl ether / 24 h / 20 °C
6: 20 °C
7: NaOH / methanol; H2O / 12 h / Heating
8: 0.340 g / H2SO4 / 0.08 h / 20 °C
9: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: Et3N / 1,2-dichloro-ethane / 20 °C
2: 1.027 g / SOCl2 / CH2Cl2; benzene / 4 h / 20 °C
3: 75 percent / diethyl ether / 24 h / 20 °C
4: 20 °C
5: NaOH / methanol; H2O / 12 h / Heating
6: 0.340 g / H2SO4 / 0.08 h / 20 °C
7: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: oxalyl chloride / CH2Cl2 / 24 h / 20 °C
2: Et3N / 1,2-dichloro-ethane / 20 °C
3: 1.027 g / SOCl2 / CH2Cl2; benzene / 4 h / 20 °C
4: 75 percent / diethyl ether / 24 h / 20 °C
5: 20 °C
6: NaOH / methanol; H2O / 12 h / Heating
7: 0.340 g / H2SO4 / 0.08 h / 20 °C
8: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: 1.027 g / SOCl2 / CH2Cl2; benzene / 4 h / 20 °C
2: 75 percent / diethyl ether / 24 h / 20 °C
3: 20 °C
4: NaOH / methanol; H2O / 12 h / Heating
5: 0.340 g / H2SO4 / 0.08 h / 20 °C
6: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: 75 percent / diethyl ether / 24 h / 20 °C
2: 20 °C
3: NaOH / methanol; H2O / 12 h / Heating
4: 0.340 g / H2SO4 / 0.08 h / 20 °C
5: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: 20 °C
2: NaOH / methanol; H2O / 12 h / Heating
3: 0.340 g / H2SO4 / 0.08 h / 20 °C
4: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
反应条件
1: 0.340 g / H2SO4 / 0.08 h / 20 °C
2: 66 percent / HBr; AcOH / 5 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Salvador, Maria A.; Oliveira, M. Manuel; Carvalho, Luis M.
Tetrahedron, 2004 , vol. 60, # 11 p. 2593 - 2599
