6,7-二甲氧基-4-苯基1,2,3,4-四氢异喹啉盐酸盐合成路线 （共 9 条）
反应条件
hydrogen; platinum(IV) oxide in ethanol
P=2660 Torr; 8 h;
参考文献
Bandaranayake, Wickramasinghe M.; Riggs, Noel V.
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 115 - 129
反应条件
triethylsilane; trifluoroacetic acid
T=20°C; 2.5 h;
参考文献
Blecha, Joseph E.; Anderson, Marc O.; Chow, Jennifer M.; Guevarra, Christle C.; Pender, Celia; Penaranda, Cristina; Zavodovskaya, Marianna; Youngren, Jack F.; Berkman, Clifford E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4026 - 4029
反应条件
1: 89 percent / lithium aluminum hydride / tetrahydrofuran / 3.5 h / 20 °C
2: 77 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
3: 66 percent / tetrahydrofuran / -78 - 20 °C
4: 65 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
5: 90 percent / TFA; Et3SiH / 2.5 h / 20 °C
View Scheme
参考文献
Blecha, Joseph E.; Anderson, Marc O.; Chow, Jennifer M.; Guevarra, Christle C.; Pender, Celia; Penaranda, Cristina; Zavodovskaya, Marianna; Youngren, Jack F.; Berkman, Clifford E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4026 - 4029
反应条件
1: 60 percent / aluminium chloride / nitrobenzene / 24 h / Ambient temperature
2: 72 percent / aq. HCl, Zn/Hg / toluene / 24 h / Heating
3: 56 percent / 95percent aq. H2SO4 / 0.5 h / 95 °C
4: 1.) Mg / 1.) ether, 2.) a) RT, 6 h, b) reflux, 1 h
5: 80 percent / H2 / PtO2 / ethanol / 8 h / 2660 Torr
View Scheme
参考文献
Bandaranayake, Wickramasinghe M.; Riggs, Noel V.
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 115 - 129
反应条件
1: 72 percent / aq. HCl, Zn/Hg / toluene / 24 h / Heating
2: 56 percent / 95percent aq. H2SO4 / 0.5 h / 95 °C
3: 1.) Mg / 1.) ether, 2.) a) RT, 6 h, b) reflux, 1 h
4: 80 percent / H2 / PtO2 / ethanol / 8 h / 2660 Torr
View Scheme
参考文献
Bandaranayake, Wickramasinghe M.; Riggs, Noel V.
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 115 - 129
反应条件
1: 1.) Mg / 1.) ether, 2.) a) RT, 6 h, b) reflux, 1 h
2: 80 percent / H2 / PtO2 / ethanol / 8 h / 2660 Torr
View Scheme
参考文献
Bandaranayake, Wickramasinghe M.; Riggs, Noel V.
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 115 - 129
反应条件
1: 2.9 g / zinc, glacial acetic acid / 4 h / Heating
2: 80 percent / H2 / PtO2 / ethanol / 8 h / 2660 Torr
View Scheme
参考文献
Bandaranayake, Wickramasinghe M.; Riggs, Noel V.
Australian Journal of Chemistry, 1981 , vol. 34, # 1 p. 115 - 129
反应条件
1: 65 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
2: 90 percent / TFA; Et3SiH / 2.5 h / 20 °C
View Scheme
参考文献
Blecha, Joseph E.; Anderson, Marc O.; Chow, Jennifer M.; Guevarra, Christle C.; Pender, Celia; Penaranda, Cristina; Zavodovskaya, Marianna; Youngren, Jack F.; Berkman, Clifford E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4026 - 4029
反应条件
1: 66 percent / tetrahydrofuran / -78 - 20 °C
2: 65 percent / pyridinium chlorochromate / CH2Cl2 / 1 h / 20 °C
3: 90 percent / TFA; Et3SiH / 2.5 h / 20 °C
View Scheme
参考文献
Blecha, Joseph E.; Anderson, Marc O.; Chow, Jennifer M.; Guevarra, Christle C.; Pender, Celia; Penaranda, Cristina; Zavodovskaya, Marianna; Youngren, Jack F.; Berkman, Clifford E.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 14 p. 4026 - 4029
