3-羟基-5-硝基苯甲酸合成路线 （共 15 条）
反应条件
hydrogen bromide; acetic acid 20 h; Heating;
参考文献
Hartung, Ingo V.; Rude, Mathew A.; Schnarr, Nathan A.; Hunziker, Daniel; Khosla, Chaitan
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11202 - 11203
反应条件
1: 86 percent / hexamethylphosphoric acid triamide / 20 h / 85 °C 2: 95 percent / AcOH; HBr / 20 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 127, # 32 p. 11202 - 11203
反应条件
1: With sulfuric acid; sodium nitrite in water T=0°C; 2: With copper(I) oxide; Cu(NO3)2*3H2O; water T=20°C; 0.0333333 h;
参考文献
Wang, Ying; Xiang, Junfeng; Jiang, Hua
Chemistry - A European Journal, 2011 , vol. 17, # 2 p. 613 - 619
反应条件
hydrogen bromide; acetic acid 22 h; Heating;
参考文献
Herlt, Anthony J.; Kibby, Jeffrey J.; Rickards, Rodney W.
Australian Journal of Chemistry, 1981 , vol. 34, # 6 p. 1319 - 1324
反应条件
1: 63 percent / MeOLi / 4 h / Heating 2: 79 percent / 48percent aq. HBr, AcOH / 22 h / Heating View Scheme
参考文献
Australian Journal of Chemistry, , vol. 34, # 6 p. 1319 - 1324
反应条件
acetyl chloride 18 h; Ambient temperature;
参考文献
Abraham; Gazze; Kennedy; Mokotoff
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1549 - 1559
反应条件
sulfuric acid; sodium carbonate in methanol; water
参考文献
Wu, Yong-Qian; Belyakov, Sergei; Hamilton, Gregory S.; Limburg, David; Steiner, Joseph P.; Vaal, Mark; Wei, Ling; Wilkinson, Douglas
Patent: US2002/165275 A1, 2002 ;
反应条件
sodium tetrahydroborate; iodine in tetrahydrofuran T=20°C; 6 h;
参考文献
Hartung, Ingo V.; Rude, Mathew A.; Schnarr, Nathan A.; Hunziker, Daniel; Khosla, Chaitan
Journal of the American Chemical Society, 2005 , vol. 127, # 32 p. 11202 - 11203
反应条件
sodium hydroxide in water T=60 - 65°C; 0.5 h;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
sodium hydroxide T=95°C; 1 h;
参考文献
Fujikura; Miigata; Hashimoto; Imai; Takenaka
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 11 p. 4092 - 4101
