3-甲氧基5-硝基苯甲酸乙酯合成路线 （共 20 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Bristol-Myers Squibb Company
Patent: US2010/227894 A1, 2010 ;
Location in patent: Page/Page column 73 ;
US 20100227894 A1
反应条件
1: in methanol T=85°C; 4 h; 2: With hydrogenchloride in methanol; water T=20°C; pH=~ 3;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 99-100 ;
WO 2009/042694 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=0 - 20°C; 16 h;
参考文献
WO2008/9750 A2, ;
Page/Page column 38 ;
反应条件
sodium methylate; sodium in methanol; ethyl acetate
反应条件
sodium hydroxide in water T=60 - 65°C; 0.5 h;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
potassium carbonate in acetone 12 h; Heating;
参考文献
Yan, Zhiqing; Chang, Yuning; Mayo, Dennis; Maslak, Veselin; Xia, Shijing; Badjic, Jovica D.
Organic Letters, 2006 , vol. 8, # 17 p. 3697 - 3700
反应条件
1: methanol With lithium T=0°C; Inert atmosphere; 2: Methyl 3,5-dinitrobenzoate RefluxInert atmosphere;
参考文献
Brandt, Gary E. L.; Blagg, Brian S. J.
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 735 - 740
反应条件
in methanol; diphenylether T=0 - 5°C;
参考文献
Nekhoroshev, A. A.; Sevbo, D. P.; Ginzburg, O. A.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, # 2 p. 313 - 317
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 2 p. 369 - 374
反应条件
methyllithium 16 h; Heating / reflux;
参考文献
WO2004/56366 A1, ;
Page/Page column 15 ;
反应条件
lithium methanolate 4 h; Heating;
参考文献
Australian Journal of Chemistry, , vol. 34, # 6 p. 1319 - 1324
