反应条件
1: 3-fluoropyridine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: N,O-dimethylacetohydroxamic acid in tetrahydrofuran; hexane T=-78 - 20°C; 1 h; 3: 2-mercaptoacetic acid methyl ester With sodium hydride in tetrahydrofuran T=0°C; 10 h; Reflux; Product distribution / selectivity;
参考文献
CRYSTALGENOMICS, INC.; PALKION, INC.; HONG, Yong, Rae; LEE, Mi, Jung; KIM, Jeong, Mi; PARK, Soobong; LEE, Wheeseong; CHOI, Jong-Ryoo; RO, Seonggu; CHO, Joong, Myung; MASAMUNE, Hiroko; ELLIOTT, Gary, T.
Patent: WO2011/56725 A1, 2011 ;
Location in patent: Page/Page column 47 ;