3-(溴甲基)-1,5-二苯基-1H-吡唑合成路线 （共 4 条）
反应条件
1: With triphenylphosphine in dichloromethane
T=0°C; 0.5 h;
2: With N-bromosuccinmide in dichloromethane
T=20°C; 15 h;
参考文献
Pommery, Nicole; Taverne, Thierry; Telliez, Aurelie; Goossens, Laurence; Charlier, Caroline; Pommery, Jean; Goossens, Jean-Francois; Houssin, Raymond; Durant, Francois; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6195 - 6206
反应条件
1.1: LiBH4 / tetrahydrofuran / 72 h / 20 °C
2.1: Ph3P / CH2Cl2 / 0.5 h / 0 °C
2.2: 340 mg / N-bromosuccinimide / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Pommery, Nicole; Taverne, Thierry; Telliez, Aurelie; Goossens, Laurence; Charlier, Caroline; Pommery, Jean; Goossens, Jean-Francois; Houssin, Raymond; Durant, Francois; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6195 - 6206
反应条件
1.1: 76 percent / ethanol / 3 h / Heating
2.1: LiBH4 / tetrahydrofuran / 72 h / 20 °C
3.1: Ph3P / CH2Cl2 / 0.5 h / 0 °C
3.2: 340 mg / N-bromosuccinimide / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Pommery, Nicole; Taverne, Thierry; Telliez, Aurelie; Goossens, Laurence; Charlier, Caroline; Pommery, Jean; Goossens, Jean-Francois; Houssin, Raymond; Durant, Francois; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6195 - 6206
反应条件
1.1: 72 percent / EtONa / ethanol / 2 h / Heating
2.1: 76 percent / ethanol / 3 h / Heating
3.1: LiBH4 / tetrahydrofuran / 72 h / 20 °C
4.1: Ph3P / CH2Cl2 / 0.5 h / 0 °C
4.2: 340 mg / N-bromosuccinimide / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Pommery, Nicole; Taverne, Thierry; Telliez, Aurelie; Goossens, Laurence; Charlier, Caroline; Pommery, Jean; Goossens, Jean-Francois; Houssin, Raymond; Durant, Francois; Henichart, Jean-Pierre
Journal of Medicinal Chemistry, 2004 , vol. 47, # 25 p. 6195 - 6206
