5-硝基-1H-吲唑-3-羧酸甲酯合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol; ethyl acetate 3 h;
参考文献
ASTEX TECHNOLOGY LIMITED
Patent: WO2005/14554 A1, 2005 ;
Location in patent: Page/Page column 67-68 ;
WO 2005/014554 A1
反应条件
thionyl chloride
T=0°C; Heating / reflux;
参考文献
SCHERING CORPORATION
Patent: WO2008/153858 A1, 2008 ;
Location in patent: Page/Page column 272 ;
WO 2008/153858 A1
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in toluene
T=70 - 80°C; P=750.075 Torr; Autoclave;
参考文献
Buchstaller, Hans-Peter; Wilkinson, Kai; Burek, Kasimir; Nisar, Yasmin
Synthesis, 2011 , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
hydrogenchloride
Heating / reflux;
参考文献
ASTEX TECHNOLOGY LIMITED
Patent: WO2004/14864 A1, 2004 ;
Location in patent: Page 70 ;
WO 2004/014864 A1
反应条件
sulfuric acid; nitric acid
T=0°C; 0.166667 h;
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
反应条件
1: sulfuric acid / 5 h / |Reflux
2: nitric acid; sulfuric acid / 0.17 h / 0 °C
View Scheme
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
