5-氟-1H-吲唑-3-羧酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid 5 h; Heating;
参考文献
Schmidt, Andreas; Snovydovych, Bohdan; Habeck, Tobias; Droettboom, Petra; Gjikaj, Mimoza; Adam, Arnold
European Journal of Organic Chemistry, 2007 , # 29 p. 4909 - 4916
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine in toluene T=80°C; P=750.075 Torr; Autoclave;
参考文献
Buchstaller, Hans-Peter; Wilkinson, Kai; Burek, Kasimir; Nisar, Yasmin
Synthesis, 2011 , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
sulfuric acid in water 16 h; Heating / reflux;
参考文献
WO2007/36727 A1, ;
Page/Page column 14-15 ;
WO 2007/036727 A1
反应条件
1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 1 h / 20 °C 2: 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; triethylamine / toluene / 80 °C / 750.08 Torr / Autoclave View Scheme
参考文献
Synthesis, , # 19 art. no. T48411SS, p. 3089 - 3098
反应条件
1.1: sodium hydroxide / water / 1 h / 50 °C 1.2: 1 h / |Cooling with ice 1.3: 20 °C / |Cooling with ice 2.1: sulfuric acid / 3 h / |Reflux View Scheme
反应条件
1: diisobutylaluminium hydride / toluene; tetrahydrofuran / -10 - 20 °C 2: manganese(IV) oxide / ethyl acetate / 20 °C View Scheme
反应条件
diisobutylaluminium hydride in tetrahydrofuran; toluene
T=-10 - 20°C;
参考文献
The University of Tokyo; Riken; NAGANO Tetsuo; OKABE Takayoshi; KOJIMA Hirotatsu; SAITO Nae; NAKANO Hirofumi; ABE Masanao; TANAKA Akiko; HONMA Teruki; YOKOYAMA Shigeyuki; TSUGANEZAWA Keiko; YUKI Hitomi
Patent: EP2565192 A1, 2013 ;
Location in patent: Paragraph 0351 ;
