N-苄氧羰基-L-亮氨酰-L-亮氨酸合成路线 (共 11 条)
反应条件
methanol; acetic acid Hydrogenation;
参考文献
Journal of Biological Chemistry, , vol. 199, p. 801,808
反应条件
1: H2 / Pd/C / methanol 2: dimethylformamide View Scheme
参考文献
Tian, Jun; Gao, Wen-Chao; Zhou, Dong-Mei; Zhang, Chi
Organic Letters, 2012 , vol. 14, # 12 p. 3020 - 3023
反应条件
1: 1 M ethylchloroformate, 0.04 M N-methylmorpholine, 0.01 M HCl / tetrahydrofuran / 0.05 h / Ambient temperature 2: 0.02 M HCl / 0.17 h 3: 1 N aq. HCl / diethyl ether View Scheme
参考文献
Yagisawa, Shiroki; Urakami, Masako
Tetrahedron Letters, 1996 , vol. 37, # 42 p. 7557 - 7560
反应条件
methylchymotrypsin in water; dimethyl sulfoxide
3 h; pH 8.8;
参考文献
West, J. Blair; Scholten, Jeff; Stolowich, N. J.; Hogg, John L.; Scott, A. I.; Wong, Chi-Huey
Journal of the American Chemical Society, 1988 , vol. 110, p. 3709 - 3710
反应条件
trifluoroacetic acid in Petroleum ether
参考文献
Ohmoto, Kazuyuki; Itagaki, Iori
Patent: US2003/153508 A1, 2003 ;
反应条件
sodium hydroxide in 1,4-dioxane; methanol
3.5 h;
参考文献
Verdoes, Martijn; Florea, Bogdan I.; Van Der Linden, Wouter A.; Renou, Didier; Van Den Nieuwendijk, Adrianus M. C. H.; Van Der Marel, Gijs A.; Overkleeft, Herman S.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 9 p. 1416 - 1426
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triphenylphosphine; 2aλ3-ioda-2,3-dioxa-cyclopenta[cd]indene-1,4-dione / chloroform / 6 h / 60 °C
2: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Tian, Jun; Gao, Wen-Chao; Zhou, Dong-Mei; Zhang, Chi
Organic Letters, 2012 , vol. 14, # 12 p. 3020 - 3023
反应条件
sodium hydrogencarbonate in ethanol
Ambient temperature;
参考文献
Sakurai,A.; Okumura,Y.
Bulletin of the Chemical Society of Japan, 1979 , vol. 52, p. 540 - 543
反应条件
potassium chloride; water; papain in N,N-dimethyl-formamide
T=25°C; pH = 8 or 9;
参考文献
Zaher, M. R.; El-Sharief, A. M. Sh.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 8 p. 740 - 743
反应条件
sodium hydrogencarbonate
参考文献
Jakubke,H.-D.; Voigt,A.
Chemische Berichte, 1966 , vol. 99, p. 2944 - 2954