1-(2-二甲基氨基甲基-4-甲氧基苯基)-乙酮合成路线 （共 5 条）
反应条件
1: With palladium diacetate; 1,3-bis-(diphenylphosphino)propane; potassium carbonate in N,N-dimethyl-formamide
T=80°C;
2: With hydrogenchloride in N,N-dimethyl-formamide
1 h;
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
in 1,2-dichloro-ethane
12 h; Heating;
参考文献
Holton, R. A.; Natalie, K. J.
Tetrahedron Letters, 1981 , vol. 22, p. 267 - 270
反应条件
1.1: H2O / 1 h
2.1: 16.1 g / BH3 / tetrahydrofuran / 5 h
3.1: Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; aq. K2CO3 / dimethylformamide / 80 °C
3.2: 80 percent / aq. HCl / dimethylformamide / 1 h
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1.1: 16.1 g / BH3 / tetrahydrofuran / 5 h
2.1: Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; aq. K2CO3 / dimethylformamide / 80 °C
2.2: 80 percent / aq. HCl / dimethylformamide / 1 h
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
反应条件
1.1: SOCl2 / 1 h / Heating
2.1: H2O / 1 h
3.1: 16.1 g / BH3 / tetrahydrofuran / 5 h
4.1: Pd(OAc)2; 1,3-bis(diphenylphosphino)propane; aq. K2CO3 / dimethylformamide / 80 °C
4.2: 80 percent / aq. HCl / dimethylformamide / 1 h
View Scheme
参考文献
Nielsen, Simon F.; Larsen, Mogens; Boesen, Thomas; Schonning, Kristian; Kromann, Hasse
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2667 - 2677
