3,3-二甲基-4-戊烯酸合成路线 （共 17 条）
反应条件
oxygen; copper dichloride; palladium dichloride in water; N,N-dimethyl-formamide from r.t. to 60 deg C;
参考文献
Guenther, Hans Juergen; Guntrum, Eberhard; Jaeger, Volker
Liebigs Annalen der Chemie, 1984 , # 1 p. 15 - 30
反应条件
Multistep reaction. Title compound not separated from byproducts;
参考文献
Kumar; Chakravarthy, P.Pawan; Shesha Rao; Reddy, P.Sunder Ram; Yadav
Tetrahedron Letters, 2002 , vol. 43, # 43 p. 7817 - 7819
反应条件
1: With sodium hydroxide
5 h; Reflux;
2: With hydrogenchloride in water
参考文献
Zhu, Yaoping; Yeng, Xueyan; Fang, Xiang; Yang, Xianjin; Ye, Lingling; Cai, Wei; Zhang, Yan; Wu, Fanhong
Tetrahedron, 2011 , vol. 67, # 6 p. 1251 - 1257
反应条件
pyridine
T=145°C; 1 h;
参考文献
Chatgilialoglu, Chryssostomos; Ingold, Keith U.
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1077 - 1081
反应条件
sodium hydroxide
4 h; Ambient temperature;
参考文献
Kleschick, William A.
Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5429 - 5433
反应条件
1: 94 percent / H2 / Lindlar catalyst / hexane; quinoline / 760 Torr
2: 96 percent / 6N NaOH / ethanol / 1.) 70 deg C, 2 h, 2.) 85-90 deg C
3: 99 percent / pyridine / 1 h / 145 °C
View Scheme
参考文献
Chatgilialoglu, Chryssostomos; Ingold, Keith U.
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1077 - 1081
反应条件
hydrogenchloride; methanol; potassium hydroxide; water; propionic acid
1) 140-150 deg C, 2a) 110 deg C, 2b) reflux, 2h; Yield given. Multistep reaction;
参考文献
Guenther, Hans Juergen; Guntrum, Eberhard; Jaeger, Volker
Liebigs Annalen der Chemie, 1984 , # 1 p. 15 - 30
反应条件
1,1,1-triethoxyethane
T=130°C; 96 h;
参考文献
Schlummer, Bjoern; Hartwig, John F
Organic letters, 2002 , vol. 4, # 9 p. 1471 - 1474
反应条件
1: 96 percent / 6N NaOH / ethanol / 1.) 70 deg C, 2 h, 2.) 85-90 deg C
2: 99 percent / pyridine / 1 h / 145 °C
View Scheme
参考文献
Chatgilialoglu, Chryssostomos; Ingold, Keith U.
Canadian Journal of Chemistry, 1983 , vol. 61, p. 1077 - 1081
反应条件
1: diethyl ether; tetrahydrofuran
2: KOH, HCl / ethanol
3: 160 °C
View Scheme
参考文献
Chatgilialoglu, Chryssostomos; Woynar, Helmut; Ingold, Keith U.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983 , p. 555 - 562
