4-甲基-3,4-二氢-2H-苯并[b][1,4]噁嗪合成路线 （共 24 条）
反应条件
1: 78 percent / POCl3 2: NaBH4 / methanol 3: NaBH4, TFA View Scheme
参考文献
Kotha, Sambasivarao; Kuki, Atsuo
Journal of the Chemical Society, Chemical Communications, 1992 , # 5 p. 404 - 406
参考文献
Kotha, Sambasivarao; Bindra, Vandana; Kuki, Atsuo
Heterocycles, 1994 , vol. 38, # 1 p. 5 - 8
反应条件
1: POCl3 2: NaBH4 View Scheme
参考文献
Kotha, Sambasivarao; Kuki, Atsuo
Journal of the Chemical Society, Chemical Communications, 1992 , # 5 p. 404 - 406
反应条件
chlorosulfonic acid T=0 - 20°C; 2 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: US2008/200471 A1, 2008 ;
Location in patent: Page/Page column 47 ;
US 20080200471 A1
反应条件
iridium catalyst Overall yield = 79 percentChromat.; regioselective reaction;
参考文献
Science, , vol. 343, # 6173 p. 853 - 857
反应条件
N-bromosuccinmide in N,N-dimethyl-formamide
参考文献
Kotha, Sambasivarao; Bindra, Vandana; Kuki, Atsuo
Heterocycles, 1994 , vol. 38, # 1 p. 5 - 8
反应条件
1: 3,4-dihydro-2H-benzo[1,4]oxazine With sodium hydride in tetrahydrofuran
T=0 - 5°C; 0.5 h;
2: methyl iodide in tetrahydrofuran
T=0 - 20°C;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: US2008/200471 A1, 2008 ;
Location in patent: Page/Page column 47 ;
US 20080200471 A1
反应条件
9-borabicyclo[3.3.1]nonane dimer in tetrahydrofuran
T=65°C; 1 h;
参考文献
Collins, Christopher J.; Lanz, Marc; Singaram, Bakthan
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3673 - 3676
反应条件
9-(2-di-tert-butylphosphanylphenyl)phenanthrene; palladium diacetate; caesium carbonate in toluene
T=70°C; 48 h;
参考文献
Toracca, Karen E.; Kuwabe, Shin-Itsu; Buchwald, Stephen L.
Journal of the American Chemical Society, 2000 , vol. 122, # 51 p. 12907 - 12908
反应条件
1: 2-(2-propenyloxy)-1-nitrobenzene With ozone in methanol
T=-78°C;
2: formaldehyd With hydrogen; palladium on activated charcoal in methanol; water
T=25°C; P=3040 Torr; 6 h;
参考文献
Bunce, Richard A.; Herron, Derrick M.; Hale, Lu Y.
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 6 p. 1031 - 1039
