(1R)-1,3,3-三甲基二环[2.2.1]庚-2-酮合成路线 （共 16 条）
反应条件
9-azanoradamantane N-oxyl; acetic acid; sodium nitrite in acetonitrile T=20°C; 5 h; air;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 59, # 12 p. 1570 - 1573
反应条件
CC-2; water in acetonitrile T=20°C; 0.666667 h;
参考文献
Journal of Chemical Research, , # 7 p. 411 - 414
反应条件
triethylamine; selenium monobromide in dichloromethane T=-20°C; 2 h;
参考文献
Heterocycles, , vol. 60, # 2 p. 299 - 302
反应条件
2: pyridine-D5; oxygen; 5,15,10,20-tetraphenylporphyrin / chloroform-d1 / 2 h / -20 °C / Irradiation 3: methyl 1-naphthyl ketone / 200 °C View Scheme
参考文献
Journal of Photochemistry and Photobiology A: Chemistry, , vol. 218, # 1 p. 41 - 47
反应条件
1-methyl-pyrrolidin-2-one; potassium hydroxide T=20°C; 4 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 31, # 22 p. 3151 - 3154
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-78°C; diastereoselective reaction;
参考文献
Goto, Sachio; Velder, Janna; El Sheikh, Sherif; Sakamoto, Yuki; Mitani, Masatoshi; Elmas, Said; Adler, Andreas; Becker, Anne; Neudoerfl, Joerg-Martin; Lex, Johann; Schmalz, Hans-Guenther
Synlett, 2008 , # 9 p. 1361 - 1365
反应条件
n-butyllithium in tetrahydrofuran; hexane T=-30°C; optical yield given as percent de;
参考文献
Goto, Sachio; Velder, Janna; El Sheikh, Sherif; Sakamoto, Yuki; Mitani, Masatoshi; Elmas, Said; Adler, Andreas; Becker, Anne; Neudoerfl, Joerg-Martin; Lex, Johann; Schmalz, Hans-Guenther
Synlett, 2008 , # 9 p. 1361 - 1365
反应条件
1.1: n-BuLi / toluene; hexane / -40 °C 1.2: 88 percent / toluene / -40 - 20 °C 2.1: 22 percent / SeO2 / p-xylene / 72 h / 140 °C View Scheme
参考文献
Abarca, Belen; Ballesteros, Rafael; Ballesteros-Garrido, Rafael; Colobert, Francoise; Leroux, Frederic R.
Tetrahedron, 2007 , vol. 63, # 42 p. 10479 - 10485
反应条件
cerium(III) chloride 1.) THF, -78 deg C, 2.) THF, RT, 1.5 h; Yield given. Multistep reaction;
参考文献
Genov, Miroslav; Kostova, Kalina; Dimitrov, Vladimir
Tetrahedron Asymmetry, 1997 , vol. 8, # 11 p. 1869 - 1876
反应条件
1: 93 percent 2: 63 percent / thionyl chloride, pyridine / deshydratation occurs also with either KHSO4 or acetic anhydride 3: m-chloroperbenzoic acid, NaHCO3 / CH2Cl2 / 1 h / 0 °C 4: 85 percent / diethyl ether / 72 h / Heating View Scheme
参考文献
Gosselin; Joulain; Laurin; Rouessac
Tetrahedron Letters, 1990 , vol. 31, # 22 p. 3151 - 3154
