2,3-二甲氧基-4-甲基苯甲酸合成路线 （共 8 条）
反应条件
sodium hydroxide in water
T=45°C; 4 h;
参考文献
Mills, Frank D.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1597 - 1600
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine in hexane
18 h; Ambient temperature;
参考文献
Gainor, James A.; Weinreb, Steven M.
Journal of Organic Chemistry, 1981 , vol. 46, # 21 p. 4317 - 4319
反应条件
sodium hydroxide
1) acetone, 24 h, reflux; 2) reflux, 10 h, water; Yield given. Multistep reaction;
参考文献
Ecker,D.J.; Loomis,L.D.; Cass,M.E.
Journal of the American Chemical Society, 1988 , vol. 110, p. 2457
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) hexane, RT, 18 h, 2.) -78 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Gainor, James A.; Weinreb, Steven M.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 2833 - 2837
反应条件
thionyl chloride in benzene
参考文献
Mills, Frank D.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1597 - 1600
反应条件
1: 78 percent
2: 83 percent / tetrahydrofuran / 22 h / Heating
3: 4.5 N hydrochloric acid / 16 h
View Scheme
参考文献
Novak, J.; Salemink, C. A.
Tetrahedron Letters, 1983 , vol. 24, # 1 p. 101 - 102
反应条件
1: 78 percent
2: 83 percent / tetrahydrofuran / 22 h / Heating
3: 4.5 N hydrochloric acid / 16 h
4: 83 percent / aq. NaOH
6: trifluoroacetic acid / 3 h / 20 °C
View Scheme
参考文献
Novak, J.; Salemink, C. A.
Tetrahedron Letters, 1983 , vol. 24, # 1 p. 101 - 102
反应条件
1: 78 percent
2: 83 percent / tetrahydrofuran / 22 h / Heating
3: 4.5 N hydrochloric acid / 16 h
4: 83 percent / aq. NaOH
6: trifluoroacetic acid / 3 h / 20 °C
7: 92 percent / H2 / PtO2 / ethyl acetate / 1 Torr
View Scheme
参考文献
Novak, J.; Salemink, C. A.
Tetrahedron Letters, 1983 , vol. 24, # 1 p. 101 - 102
