Z-PRO-LEU-GLY-OET合成路线 （共 9 条）
参考文献
Zaoral; Rudinger
Collection of Czechoslovak Chemical Communications, 1955 , vol. 20, p. 1183,1185
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Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
2-N-methylamino-1,3,2-dioxaphospholane in acetonitrile
T=30°C; 20 h;
参考文献
Kawanobe, Wataru; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru
Chemistry Letters, 1982 , p. 825 - 828
反应条件
hydrogenchloride; triethylamine; sodium chloride in chloroform; water; ethyl acetate
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4242507 A1, 1980 ;
反应条件
2-N-methylamino-1,3,2-dioxaphospholane in acetonitrile
T=30°C; 20 h;
参考文献
Kawanobe, Wataru; Yamaguchi, Kazuo; Nakahama, Seiichi; Yamazaki, Noboru
Chemistry Letters, 1982 , p. 825 - 828
反应条件
chloroform; triethylamine; isobutyl chloroformate
anschliessend Behandeln mit L-Leucin-<4-nitro-phenylester>-hydrobromid und Triaethylamin und nachfolgend mit Glycin-aethylester;
参考文献
Goodman; Stueben
Journal of the American Chemical Society, 1959 , vol. 81, p. 3980,3982
反应条件
hydrogen bromide; acetic acid
Behandeln des Reaktionsprodukts in CHCl3 mit 1-Benzyloxycarbonyl-L-prolin und Triaethylamin;
参考文献
Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
1: ethyl acetate; dicyclohexylcarbodiimide
2: triethylamine; CHCl3
3: HBr; acetic acid / Behandeln des Reaktionsprodukts in CHCl3 mit 1-Benzyloxycarbonyl-L-prolin und Triaethylamin
View Scheme
参考文献
Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
1: triethylamine; CHCl3
2: HBr; acetic acid / Behandeln des Reaktionsprodukts in CHCl3 mit 1-Benzyloxycarbonyl-L-prolin und Triaethylamin
View Scheme
参考文献
Bodanszky; du Vigneaud
Journal of the American Chemical Society, 1959 , vol. 81, p. 5688,5689, 5690
Biochemical Preparations, 1962 , vol. 9, p. 110,111 Anm. 2
反应条件
sodium hydroxide; acetone
参考文献
Ressler; du Vigneaud
Journal of the American Chemical Society, 1954 , vol. 76, p. 3107
