2-氨基-3-氯苯甲酸甲酯合成路线 （共 13 条）
反应条件
1.1: 23 percent / pyridine / 20 °C
2.1: 100 percent / K2CO3 / dimethylformamide / 4 h / 120 °C
3.1: t-BuOK / toluene / 0.5 h / Heating
3.2: 59 percent / conc. HCl / acetic acid / 5 h / Heating
4.1: 84 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C
View Scheme
参考文献
Kondo, Kazumi; Ogawa, Hidenori; Yamashita, Hiroshi; Miyamoto, Hisashi; Tanaka, Michinori; Nakaya, Kenji; Kitano, Kazuyoshi; Yamamura, Yoshitaka; Nakamura, Shigeki; Onogawa, Toshiyuki; Mori, Toyoki; Tominaga, Michiaki
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1743 - 1754
反应条件
1: 61 percent / KF / Cl[(2-norbornyl)2PH](2'-Me2N-1,1'-biphenyl)Pd(II) / dioxane / 110 °C
2: 97 percent / LiOH / methanol; tetrahydrofuran; H2O
View Scheme
参考文献
Liu, Bin; Moffett, Kristofer K.; Joseph, Rhoda W.; Dorsey, Bruce D.
Tetrahedron Letters, 2005 , vol. 46, # 11 p. 1779 - 1782
反应条件
1: With Na2WO4·2H2O; sulfuric acid; dihydrogen peroxide in methanol; water
T=40°C; pH=0.5; 2 h;
2: With potassium hydroxide in methanol; water; toluene
T=20 - 30°C; 12 h; Reagent/catalystTemperaturepH-valueSolvent;
参考文献
IHARA CHEMICAL INDUSTRY CO., LTD.; Tani, Shinki; Yadomatsu, Nami; Ikumi, Akiko; Hirano, Yuuki; Ido, Takuya
Patent: US2014/163256 A1, 2014 ;
Location in patent: Paragraph 0163-0164 ;
