(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
1: HCOONH4 / Pd-C / ethanol / 6 h / Heating 2: Jone's reagent / acetone / 8 h / 0 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 37, # 12 p. 1221 - 1227
反应条件
2: chromium trioxide, aq. sulfuric acid 3: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
反应条件
1: chromium trioxide, aq. sulfuric acid 2: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
反应条件
1: With n-butyllithium; (S)-TRIOZ; (R)-(-)-4-phenyl-2-oxazolidinone in tetrahydrofuran T=-78°C; 2: With lithium hydroxide; water; dihydrogen peroxide in tetrahydrofuran optical yield given as percent ee;
参考文献
Tetrahedron Asymmetry, , vol. 20, # 5 p. 635 - 640
反应条件
Candida antarctica lipase A Phe149Tyr/Ile150Asn/Phe233Gly in acetonitrile T=20°C; aq. phosphate bufferaq. bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 20 p. 7038 - 7042
反应条件
Candida antarctica lipase A Phe149Tyr/Ile150Asn/Phe233Gly in acetonitrile T=20°C; aq. phosphate bufferaq. bufferEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 132, # 20 p. 7038 - 7042
反应条件
water; Candida rugosa lipase in cyclohexane T=45°C; 2 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
water; Candida rugosa lipase in cyclohexane T=45°C; 72 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
water; Candida rugosa lipase in cyclohexane T=45°C; 47 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 4.3 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
