(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
1: dichloromethane With n-butyllithium in tetrahydrofuran T=-100°C; Metallation; 0.166667 h; 2: 4,4,5,5-tetramethyl-2-(1-phenylethyl)-1,3,2-dioxaborolane With zinc(II) chloride in tetrahydrofuran; diethyl ether T=-100 - 20°C; Substitution; 3: With sodium chlorite in tetrahydrofuran; diethyl ether Oxidation; 48 h; Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 7 p. 611 - 612
反应条件
potassium phosphate buffer; Rhodococcus sp. AJ270 T=30°C; Hydrolysis; kinetic resolution; pH=7.0; 10 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 11, # 5 p. 1123 - 1135
反应条件
N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 8 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2010/234610 A1, ;
Page/Page column 6 ;
反应条件
N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 3 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2010/234610 A1, ;
Page/Page column 6 ;
反应条件
DAHP; manganese sulphate; dipotassium hydrogenphosphate; Phenylmalonic acid; water; magnesium sulfate; iron(II) sulfate; anhydrous zinc sulfate; peptone; yeast extract; 5-[(3AS,4S,6AR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid T=30°C; 120 h; other α-methyl-α-arylmalonic acids; enzyme-mediated asymmetric decarboxylation of disubstituted malonic acids, absolute configurations of products; Product distribution;
参考文献
Journal of the American Chemical Society, , vol. 112, # 10 p. 4077 - 4078
反应条件
1.1: 99 percent / K2CO3 / acetone / Heating 2.1: 49 percent / LHMDS / tetrahydrofuran / 1 h / -78 °C 3.1: 75 percent / K2CO3 / acetone / Heating 4.1: H2; cinchonine / Pd/C / ethyl acetate / 1 h 4.2: NaOH; Br2 / H2O; dioxane / 3 h 4.3: Na2SO3 / H2O; dioxane View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3986 - 3994
反应条件
1.1: 49 percent / LHMDS / tetrahydrofuran / 1 h / -78 °C 2.1: 75 percent / K2CO3 / acetone / Heating 3.1: H2; cinchonine / Pd/C / ethyl acetate / 1 h 3.2: NaOH; Br2 / H2O; dioxane / 3 h 3.3: Na2SO3 / H2O; dioxane View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3986 - 3994
反应条件
1.1: 75 percent / K2CO3 / acetone / Heating 2.1: H2; cinchonine / Pd/C / ethyl acetate / 1 h 2.2: NaOH; Br2 / H2O; dioxane / 3 h 2.3: Na2SO3 / H2O; dioxane View Scheme
参考文献
European Journal of Organic Chemistry, , # 23 p. 3986 - 3994
反应条件
Birman's catalyst; benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 35 p. 5887 - 5890
反应条件
Birman's catalyst; benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 12 h; Resolution of racemate; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 35 p. 5887 - 5890
