(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
tris(hydroxymethyl)methylamine hydrochloride T=35°C; 168 h; var. pH, ionic strength, ester conc., and stirring speed; Product distribution;
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , # 6 p. 1333 - 1336
反应条件
benzoic acid anhydride; N-ethyl-N,N-diisopropylamine; Birman's catalyst in dichloromethane T=20°C; 6 h; Resolution of racemate; Product distribution / selectivity;
参考文献
US2010/234610 A1, ;
Page/Page column 8-9 ;
反应条件
Birman's catalyst; benzoic acid anhydride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 72 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Shiina, Isamu; Nakata, Kenya; Ono, Keisuke; Onda, Yu-Suke; Itagaki, Makoto
Journal of the American Chemical Society, 2010 , vol. 132, # 33 p. 11629 - 11641
反应条件
Nocardia diaphanozonaria cells; glycerol; peptone; beef extract; yeast extract in water T=30°C; pH=7.0; 48 h; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 68, # 19 p. 7234 - 7242
反应条件
1: With ozone in acetone T=-78°C; 2: With chromium(VI) oxide; sulfuric acid in acetone T=0°C; Jones oxidation; 0.25 h;
参考文献
Organic Letters, , vol. 5, # 12 p. 2111 - 2114
反应条件
1: With ozone in acetone T=-78°C; 2: With jones reagent in acetone T=0°C; Jones oxidation; 0.25 h; Further stages.;
参考文献
Organic Letters, , vol. 9, # 6 p. 1041 - 1044
反应条件
1: With sodium periodate; silica gel in dichloromethane Oxidation; 2: Oxidation; Jones oxidation;
参考文献
Carde, Lydia; Davies, Huw; Geller, Thomas P.; Roberts, Stanley M.
Tetrahedron Letters, 1999 , vol. 40, # 29 p. 5421 - 5424
反应条件
1.1: sec-BuLi / tetrahydrofuran; cyclohexane / 1 h / -78 °C 1.2: (+)-1-(5-Cl-2-CH3NHC6H3)-1,2,3,4-tetrahydroisoquinoline / tetrahydrofuran; cyclohexane / 1 h / -78 - 0 °C 2.1: 64 percent / AcOH; ceric ammonium nitrate / acetonitrile; H2O / 0.25 h View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 19 p. 4602 - 4607
反应条件
PIPES buffer; subtilisin Carlsberg enzyme in water; toluene Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 120, # 23 p. 5605 - 5610
反应条件
sodium chlorite; dipotassium hydrogenphosphate; 2-methyl-but-2-ene in tert-butyl alcohol T=20°C; Oxidation; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 64, # 26 p. 9704 - 9710
