(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
1: LDA 2: LDA 3: H2 / Pd/C 4: KOH / ethanol 6: chromium trioxide, aq. sulfuric acid 7: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
反应条件
1: H2 / Pd/C 2: KOH / ethanol 4: chromium trioxide, aq. sulfuric acid 5: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
反应条件
1: LDA 2: H2 / Pd/C 3: KOH / ethanol 5: chromium trioxide, aq. sulfuric acid 6: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
反应条件
chromium(VI) oxide; sulfuric acid in acetone Jones Oxidation;
参考文献
WO2004/76464 A2, ;
Page/Page column 69 ;
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; 12 h;
参考文献
Chavda, Sameer; Coulbeck, Elliot; Dingjan, Marco; Eames, Jason; Flinn, Anthony; Northen, Julian
Tetrahedron Asymmetry, 2008 , vol. 19, # 13 p. 1536 - 1548
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; 12 h;
参考文献
Chavda, Sameer; Coulbeck, Elliot; Dingjan, Marco; Eames, Jason; Flinn, Anthony; Northen, Julian
Tetrahedron Asymmetry, 2008 , vol. 19, # 13 p. 1536 - 1548
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in water; acetonitrile T=35°C; 4 h; aq. phosphate buffer;
参考文献
Galletti, Paola; Pori, Matteo; Giacomini, Daria
Synlett, 2010 , # 17 p. 2644 - 2648
反应条件
C32H12BF24(1-)*C54H71IrNP(1+); hydrogen; caesium carbonate in methanol T=45°C; 4 h; optical yield given as percent eeenantioselective reaction;
参考文献
Zhu, Shou-Fei; Yu, Yan-Bo; Li, Shen; Wang, Li-Xin; Zhou, Qi-Lin
Angewandte Chemie - International Edition, 2012 , vol. 51, # 35 p. 8872 - 8875
反应条件
1: With (R)-BINOL-SnCl4 in dichloromethane; toluene T=-78°C; enantioselective protonation; 1 h; 2: With hydrogenchloride in dichloromethane; toluene Hydrolysis; Further stages. Title compound not separated from byproducts.;
参考文献
Journal of the American Chemical Society, , vol. 122, # 34 p. 8120 - 8130
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=20°C; 12 h;
参考文献
Coulbeck, Elliot; Eames, Jason
Tetrahedron Asymmetry, 2008 , vol. 19, # 19 p. 2223 - 2233
