2,4-二甲氧基-6-甲基嘧啶合成路线 （共 21 条）
参考文献
Andrisano
Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1944 , vol. 5, p. 48,51
反应条件
1: 40 percent / Na2CO3 / CH2Cl2 / 48 h / 150 °C 2: 75 percent / HCl / CHCl3 / 10 h / Ambient temperature View Scheme
参考文献
Bhat, Sunita
Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 3 p. 683 - 690
反应条件
potassium hydroxide in water
T=20°C; 6 h;
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
Location in patent: Page/Page column 197 ;
US 20120295874 A1
反应条件
lithium carbonate in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=25°C; Methylation; 1 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
反应条件
1: trichlorophosphate / 3 h / 105 °C
2: potassium hydroxide / water / 6 h / 20 °C
View Scheme
参考文献
CORNELL UNIVERSITY; COFERON, INC.; PURDUE RESEARCH FOUNDATION
Patent: US2012/295874 A1, 2012 ;
US 20120295874 A1
反应条件
sodium hydroxide
T=20°C; Methylation; hydrolysis; 1 h;
参考文献
Gambacorta, Augusto; Farah, Mohamed Elmi; Tofani, Daniela
Tetrahedron, 1999 , vol. 55, # 43 p. 12615 - 12628
参考文献
Marshall; Walker
Journal of the Chemical Society, 1951 , p. 1004,1015
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, vol. 24, p. 84
反应条件
methanol
Unter Kuehlung;
参考文献
Chi; Ling
Scientia Sinica (English Edition), 1955 , vol. 4, p. 119,125
反应条件
sodium methylate; N,N-dimethyl-aniline; trichlorophosphate
1.) 100 deg C, 3 h, 2.) 0 deg C, 2 h; reflux, 3 h; Yield given. Multistep reaction;
参考文献
Wada; Yasuda; Kanatomo
Synthesis, 1988 , # 10 p. 771 - 775
反应条件
1: POCl3
2: methanol
View Scheme
参考文献
Yamanaka
Chemical and Pharmaceutical Bulletin, 1959 , vol. 7, p. 505,508
