bromine in anhydrous disodium hydrogen phosphate

N-bromosuccinmide in acetonitrile 24 h; Reflux; regioselective reaction;

1: methanol / 24 h / 60 °C 2: N-bromosuccinmide / acetonitrile / 24 h / |Reflux View Scheme

1: 3-bromo-2-chloro-6-methoxypyridine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20°C; 2 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-20°C; 0.5 h; Inert atmosphere;