(S)-(-)-2-(三氟乙酰胺)琥珀酸酐合成路线 （共 5 条）
反应条件
sodium tetrahydroborate in tetrahydrofuran T=0°C;
参考文献
Bartrum, Hannah E.; Jackson, Richard F. W.
Synlett, 2009 , # 14 p. 2257 - 2260
参考文献
Weygand et al.
Chemische Berichte, 1957 , vol. 90, p. 1879,1890
Show Details
Gong, Bing; Lynn, David G.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4763 - 4765
反应条件
1: 2.) thionyl chloride / 1.) 0 deg C -> room temperature, 20 min, 2.) reflux, 1h
2: 93 percent / 2 h / Ambient temperature
View Scheme
参考文献
Gani, David; Young, Douglas W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2393 - 2398
反应条件
hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); N,N,N',N,-tetramethylethylenediamine
1.) THF, reflux, 8h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Castano; Echavarren
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4783 - 4786
反应条件
hydrogenchloride; bis(1,5-cyclooctadiene)nickel (0); N,N,N',N,-tetramethylethylenediamine
1.) THF, reflux, 8h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Castano; Echavarren
Tetrahedron Letters, 1990 , vol. 31, # 33 p. 4783 - 4786
