2-(4-三氟甲基苯基)乙胺合成路线 （共 11 条）
反应条件
ammonia; hydrogen in methanol P=2585.81 Torr;
参考文献
WO2012/35078 A1, ;
Page/Page column 67 ;
WO 2012/035078 A1
反应条件
samarium diiodide; water; isopropylamine in tetrahydrofuran
参考文献
Tetrahedron Letters, , vol. 48, # 32 p. 5707 - 5710
反应条件
1: 48percent HBr / 12 h / Heating 2: tetrabutylammonium bromide / CH2Cl2; H2O / 12 h / Heating 3: 53 percent / lithium aluminum hydride, aluminum chloride / diethyl ether / 8 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 21 p. 4247 - 4252
反应条件
1: tetrabutylammonium bromide / CH2Cl2; H2O / 12 h / Heating 2: 53 percent / lithium aluminum hydride, aluminum chloride / diethyl ether / 8 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 46, # 21 p. 4247 - 4252
反应条件
1: LiAlH4 / diethyl ether 2: aq. HBr 3: aq. ethanol 4: LiAlH4, AlCl3 / diethyl ether View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 48, p. 125 - 132
反应条件
1: SOCl2 / Heating 2: Py / Heating 3: LiAlH4 / diethyl ether 4: aq. HBr 5: aq. ethanol 6: LiAlH4, AlCl3 / diethyl ether View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 48, p. 125 - 132
反应条件
1: Py / Heating 2: LiAlH4 / diethyl ether 3: aq. HBr 4: aq. ethanol 5: LiAlH4, AlCl3 / diethyl ether View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 48, p. 125 - 132
反应条件
diethylamine in dichloromethane T=0 - 20°C; 0.666667 h;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93231 A2, 2003 ;
Location in patent: Page/Page column 48-49 ;
WO 03/093231 A2
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=0 - 20°C; 0.666667 h;
参考文献
MERCK and CO., INC.
Patent: WO2005/80371 A1, 2005 ;
Location in patent: Page/Page column 49 ;
WO 2005/080371 A1
反应条件
1: sodium carbonate / chloroform / 0 - 20 °C 2: phosphorus pentoxide; trichlorophosphate / 2 h / 105 °C View Scheme
参考文献
NOVARTIS AG; Bock, Mark Gary; Gaul, Christoph; Gummadi, Venkateshwar Rao; Moebitz, Henrik; Sengupta, Saumitra
Patent: US2014/45872 A1, 2014 ;
