S-1,2,3,4-四氢异喹啉-3-羧酸苄酯盐酸盐合成路线 (共 12 条)
反应条件
sodium hydrogencarbonate in ethyl acetate Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 31, # 1 p. 312 - 314
反应条件
PPA T=95 - 105°C; 4 h;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 10 p. 1953 - 1961
反应条件
1: With ammonia in dichloromethane T=5 - 30°C; 4 h; 2: With sodium carbonate; triethylamine in dichloromethane; water T=30°C; 4 h;
参考文献
LUPIN LIMITED
Patent: WO2004/54980 A1, 2004 ;
Location in patent: Page 24;13;16 ;
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide in dichloromethane Ambient temperature;
参考文献
Klutchko; Blankley; Fleming; Hinkley; Werner; Nordin; Holmes; Hoefle; Cohen; Essenburg
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1953 - 1961
反应条件
triethylamine in dichloromethane T=-15 - -10°C; 4 h;
参考文献
Singh, Girij Pal; Godbole, Himanshu M.; Nehate, Sagar P.; Mahajan, Pravin R.
Synthetic Communications, 2005 , vol. 35, # 2 p. 243 - 248
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Stingl; Martens; Wallbaum
Tetrahedron Asymmetry, 1992 , vol. 3, # 2 p. 223 - 226
反应条件
sodium hydroxide in water 15 h; Ambient temperature;
参考文献
Kammermeier; Lerch; Sommer
Synthesis, 1992 , # 11 p. 1157 - 1160
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Stingl; Martens; Wallbaum
Tetrahedron Asymmetry, 1992 , vol. 3, # 2 p. 223 - 226
反应条件
triethylamine in dichloromethane T=-15 - -10°C; 4 h;
参考文献
Singh, Girij Pal; Godbole, Himanshu M.; Nehate, Sagar P.; Mahajan, Pravin R.
Synthetic Communications, 2005 , vol. 35, # 2 p. 243 - 248
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Stingl; Martens; Wallbaum
Tetrahedron Asymmetry, 1992 , vol. 3, # 2 p. 223 - 226