2,4-二氧代-2,4-二氢-1H-苯并[1,3]恶嗪-6-羧酸合成路线 （共 6 条）
反应条件
in tetrahydrofuran 24 h; Reflux;
参考文献
WO2012/59442 A2, ;
Page/Page column 81-82 ;
WO 2012/059442 A2
反应条件
1: 1 N NaOH / 2 h / Heating 2: benzene; H2O / 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 6 p. 735 - 742
反应条件
1: potassium permanganate / water / 90 °C 2: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol 3: tetrahydrofuran / 24 h / Reflux View Scheme
参考文献
WO2012/59442 A2, ;
WO 2012/059442 A2
反应条件
1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol 2: tetrahydrofuran / 24 h / Reflux View Scheme
参考文献
WO2012/59442 A2, ;
WO 2012/059442 A2
反应条件
in water; benzene 4 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 6 p. 735 - 742
反应条件
4-(N,N-dimethlyamino)pyridine in DMF (N,N-dimethyl-formamide)
T=60°C; 3 h;
参考文献
Badorc, Alain; Bono, Francoise; Bordes, Marie-Francoise; Guillo, Nathalie; Herbert, Jean-Marc
Patent: US2005/203126 A1, 2005 ;
Location in patent: Page/Page column 13 ;
US 20050203126 A1
