3-溴-4-甲氧基苯乙酸合成路线 （共 22 条）
反应条件
bromine; acetic acid T=0 - 20°C;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/62661 A1, 2004 ;
Location in patent: Page/Page column 27-28 ;
WO 2004/062661 A1
反应条件
sodium hydroxide in methanol 1.5 h; Ambient temperature;
参考文献
Wasserman, Harry H.; Wang, Jianji
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5581 - 5586
反应条件
1: 79 percent / Br2, AlCl3 / CH2Cl2 / 0.33 h / 0 °C 2: 90 percent / aq. NaOH / methanol / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 16 p. 5581 - 5586
反应条件
1: aqueous NaOH / 50 °C 2: benzene; HCl / 0 °C 3: ethanol 4: aq.-ethanolic NaOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 1780,1782
参考文献
Journal of the Chemical Society, , p. 1780,1782
反应条件
1: ethanol 2: aq.-ethanolic NaOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 1780,1782
反应条件
1: benzene; HCl / 0 °C 2: ethanol 3: aq.-ethanolic NaOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 1780,1782
反应条件
1: Br2, aq. AcOH, I2 2: HCHO, aq. NaOH 3: HCl 5: (alkaline hydrolysis) View Scheme
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2234 - 2238
反应条件
1: acetic acid; bromine 2: hydrogen chloride 3: aq. NaOH solution 4: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 53, p. 557,563; dtsch. Ref. S. 92
Chem.Abstr., , p. 4223
反应条件
1: chloroform; bromine 2: aq. NaOH solution 3: ethanolic KOH-solution View Scheme
参考文献
Yakugaku Zasshi, , vol. 53, p. 557,563; dtsch. Ref. S. 92
Chem.Abstr., , p. 4223
