773837-37-9合成路线

参考文献

Larsen, Jane; Madsen, Dorte; Poulsen, Jens-Aage; Poulsen, Tina D.; Keiding, Soren R.; Thogersen, Jan
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773837-37-9+88043-21-4N-Boc-反式-4-对甲苯磺酰氧基-L-脯氨酸甲酯→487048-28-2顺式-N-BOC-4-氰基-L-脯氨酸甲酯

参考文献

WO2009/137130 A2, ;

Page/Page column 182-183 ;

773837-37-9+84520-67-2(2S,4R)-BOC-Γ-甲磺酰基氧甲基脯氨酸甲酯→487048-28-2顺式-N-BOC-4-氰基-L-脯氨酸甲酯

参考文献

US2013/115194 A1, ;

Paragraph 0412 ;

773837-37-9+88043-21-4N-Boc-反式-4-对甲苯磺酰氧基-L-脯氨酸甲酯→194163-91-2反式-N-BOC-4-氰基-L-脯氨酸甲酯+487048-28-2顺式-N-BOC-4-氰基-L-脯氨酸甲酯

参考文献

Angewandte Chemie - International Edition, , vol. 52, # 36 p. 9539 - 9543
Angew. Chem., , vol. 125, # 36 p. 9718 - 9722

773837-37-9+455-13-04-碘三氟甲苯→455-18-5对三氟甲基苯腈

参考文献

Yapuri, Umanadh; Palle, Sadanandam; Gudaparthi, Omprakash; Narahari, Srinivasa Reddy; Rawat, Dhwajbahadur K.; Mukkanti, Khagga; Vantikommu, Jyothi
Tetrahedron Letters, 2013 , vol. 54, # 35 p. 4732 - 4734

773837-37-9+493024-39-83-氯-5-氟溴苄→493038-93-03-氯-5-氟苯乙腈

参考文献

EP2530078 A1, ;

Page/Page column 118 ;

773837-37-9+51632-16-71-溴甲基-3-苯氧基苯→51632-29-23-苯氧基苯乙腈

参考文献

Dou, Dengfeng; Mandadapu, Sivakoteswara Rao; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 19 p. 5749 - 5755

773837-37-9+53874-66-13-苯氧基苄氯→51632-29-23-苯氧基苯乙腈

参考文献

The Board of Trustees of the University of Illinois
Patent: US2012/22024 A1, 2012 ;
Location in patent: Page/Page column 25 ;
US 20120022024 A1

773837-37-9+72641-13-5四氢呋喃-2-基甲基甲烷磺酸酯→33414-62-92-(四氢呋喃-2-基)乙腈

参考文献

Erickson, Shawn David; Baldwin, John J.; Dolle III, Roland Ellwood; Inglese, James; Ohlmeyer, Michael H.J.; Ho, Koc-Kan; Bohnstedt, Adolph C.; Kultgen, Steven G.; Conti, Paolo Giovanni Martino; Leysen, Dirk; van der Louw, Jaap
Patent: US2004/87601 A1, 2004 ;
Location in patent: Page 27 ;
US 20040087601 A1

773837-37-9+162744-60-74-溴-2,6-二氟苄基溴→537033-52-62-(4-溴-2,6-二氟苯基)乙腈

参考文献

GLAXOSMITHKLINE LLC; GHERGUROVICH, Jonathan, Michael; MOORE, Michael, Lee; PARRISH, Cynthia, Ann; RIDGERS, Lance, Howard; YU, Hongyi
Patent: WO2013/28447 A1, 2013 ;
Location in patent: Page/Page column 111 ;