2-(氯甲基)二苯并[b,d]呋喃合成路线 （共 4 条）
反应条件
thionyl chloride in dichloromethane
T=80°C; 0.333333 h; Microwave irradiation;
参考文献
ExonHit Therapeutics SA; ALLERGAN, INC.
Patent: US2012/214837 A1, 2012 ;
Location in patent: Page/Page column 27 ;
US 20120214837 A1
反应条件
hydrogenchloride; phosphoric acid; acetic acid
T=100°C; 7 h;
参考文献
Janczewski, Marian; Kutyla, Romualda
Polish Journal of Chemistry, 1980 , vol. 54, # 7/8 p. 1401 - 1411
反应条件
1.1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C
1.2: 0.33 h / 20 °C
2.1: thionyl chloride / dichloromethane / 0.33 h / 80 °C / Microwave irradiation
View Scheme
参考文献
ExonHit Therapeutics SA; ALLERGAN, INC.
Patent: US2012/214837 A1, 2012 ;
US 20120214837 A1
反应条件
hydrogenchloride; zinc(II) chloride; Petroleum ether
参考文献
Johnson et al.
Journal of Organic Chemistry, 1956 , vol. 21, p. 457,458
