N-苄氧羰基-N’-叔丁氧羰基-L-鸟氨酸合成路线 （共 13 条）
反应条件
1: copper(II) complex of Nδ-tert-butoxycarbonyl-L-ornithine With 8-hydroxy-quinoline; sodium carbonate in acetone 1 h; 2: benzyl chloroformate With 1-hydroxy-pyrrolidine-2,5-dione in water T=-5°C; 0.5 h;
参考文献
Wiejak; Masiukiewicz; Rzeszotarska
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 9 p. 1189 - 1191
反应条件
sodium hydroxide; triethylamine in methanol T=20°C; 24 h;
参考文献
Halim, Dany; Caron, Karine; Keillor, Jeffrey W.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 305 - 308
参考文献
WO2006/83440 A2, ;
Page/Page column 113 ;
反应条件
1: di-tert-butyl dicarbonate; L-(+)-ornithine hydrochloride With sodium hydroxide; copper diacetate in water; acetone 44 h; 2: With 8-hydroxy-quinoline; sodium carbonate in water; acetone 1.5 h; 3: N-(benzyloxycarbonyloxy)-succinimide in water; acetone T=20°C; 1.5 h;
参考文献
Organic Preparations and Procedures International, , vol. 34, # 5 p. 531 - 537
参考文献
Justus Liebigs Annalen der Chemie, , vol. 702, p. 188 - 196
反应条件
1.1: Na2CO3 / H2O; acetone / 0.5 h / -10 °C 2.1: Cu(CH3COO)2; NaOH / H2O; acetone / 44 h 2.2: 8-quinolinol; Na2CO3 / acetone; H2O / 1.5 h 2.3: H2O; acetone / 1.5 h / 20 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 34, # 5 p. 531 - 537
反应条件
2: MgO / dioxane; H2O View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 679, p. 221 - 231
反应条件
triethylamine in tert-butyl alcohol
参考文献
Journal of the Chemical Society [Section] C: Organic, , p. 2632 - 2636
反应条件
Acylation; Multistep reaction;
参考文献
Masiukiewicz, Elzbieta; Rzeszotarska, Barbara; Szczerbaniewicz, Jaroslaw
Organic Preparations and Procedures International, 1992 , vol. 24, # 2 p. 191 - 194
反应条件
1: copper(II) View Scheme
参考文献
FEBS Journal, , vol. 280, # 8 p. 1807 - 1817
